Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04DZP
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| Former ID |
DNC003617
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| Drug Name |
(H-261)Boc-His-Pro-Phe-His-Leu(OH)-Val-Ile-His-OH
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C54H80N14O11
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| Canonical SMILES |
CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)O)NC(=O)C(C(C)C)NC(C(CC(C)C)NC(=O)C(CC2=CN=CN2)NC(=O)C(CC3=CC=CC=C3)NC(=O)C4CCCN4C(=O)C(CC5=CN=CN5)NC(=O)OC(C)(C)C)O
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| InChI |
1S/C54H80N14O11/c1-10-32(6)44(50(74)64-41(52(76)77)23-36-26-57-29-60-36)67-49(73)43(31(4)5)66-47(71)37(19-30(2)3)61-46(70)39(21-34-24-55-27-58-34)62-45(69)38(20-33-15-12-11-13-16-33)63-48(72)42-17-14-18-68(42)51(75)40(22-35-25-56-28-59-35)65-53(78)79-54(7,8)9/h11-13,15-16,24-32,37-44,47,66,71H,10,14,17-23H2,1-9H3,(H,55,58)(H,56,59)(H,57,60)(H,61,70)(H,62,69)(H,63,72)(H,64,74)(H,65,78)(H,67,73)(H,76,77)
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| InChIKey |
UIOXZRLXAROYRL-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Angiotensinogenase renin (REN) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Renin-angiotensin system | |||
| Pathwhiz Pathway | Angiotensin Metabolism | |||
| Reactome | Metabolism of Angiotensinogen to Angiotensins | |||
| WikiPathways | ACE Inhibitor Pathway | |||
| Metabolism of Angiotensinogen to Angiotensins | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Renin inhibitors. Dipeptide analogues of angiotensinogen incorporating transition-state, nonpeptidic replacements at the scissile bond. J Med Chem. 1987 Oct;30(10):1729-37. | |||
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