Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04EFK
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| Former ID |
DCL000766
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| Drug Name |
DDP-225
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| Synonyms |
AA-10021; AA-10025; AA-10026; 4-(2-fluorophenyl)-6-methyl-2-piperazin-1-ylthieno[2,3-d]pyrimidine hydrate hydrochloride
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| Drug Type |
Small molecular drug
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| Indication | Irritable bowel syndrome [ICD-11: DD91.0; ICD-10: K55-K64, K58; ICD-9: 564.1, 787.91] | Phase 2 | [1] | |
| Chronic functional vomiting [ICD-11: DD90.4; ICD-10: R11.10; ICD-9: 536.2] | Discontinued in Phase 2 | [1] | ||
| Company |
Dynogen
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| Structure |
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Download2D MOL |
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| Formula |
C17H20ClFN4OS
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| Canonical SMILES |
CC1=CC2=C(N=C(N=C2S1)N3CCNCC3)C4=CC=CC=C4F.O.Cl
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| InChI |
1S/C17H17FN4S.ClH.H2O/c1-11-10-13-15(12-4-2-3-5-14(12)18)20-17(21-16(13)23-11)22-8-6-19-7-9-22;;/h2-5,10,19H,6-9H2,1H3;1H;1H2
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| InChIKey |
SAURKKOJWIFYSR-UHFFFAOYSA-N
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| CAS Number |
CAS 476148-82-0
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 3 receptor (5HT3R) | Target Info | Modulator | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Emerging drugs for irritable bowel syndrome. Expert Opin Emerg Drugs. 2006 May;11(2):293-313. | |||
| REF 2 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. | |||
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