Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04EFQ
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| Drug Name |
Benzamide derivative 19
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| Synonyms |
PMID25470667-Compound-Figure5-14
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| Drug Type |
Small molecular drug
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| Company |
ELI LILLY AND COMPANY ARNOLD, Macklin, Brian BEAUCHAMP, Thomas, James CANADA, Emily, Jane HEMBRE, Erik, James LU, Jianliang RIZZO, John, Robert SCHAUS, John, Mehnert SHI, Qing
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| Structure |
 |
Download2D MOL |
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| Formula |
C25H26N4O3
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| Canonical SMILES |
CCOC1=CC=C(C=C1)C(=O)NC2(CC2)C(=O)NC3CCC4=CC=CC=C4N5C3=NC=C5
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| InChI |
1S/C25H26N4O3/c1-2-32-19-10-7-18(8-11-19)23(30)28-25(13-14-25)24(31)27-20-12-9-17-5-3-4-6-21(17)29-16-15-26-22(20)29/h3-8,10-11,15-16,20H,2,9,12-14H2,1H3,(H,27,31)(H,28,30)/t20-/m1/s1
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| InChIKey |
JIKPZJNVLNBRBQ-HXUWFJFHSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Diacylglycerol acyltransferase 1 (DGAT1) | Target Info | Inhibitor | [1] |
| Target's Patent Info | Diacylglycerol acyltransferase 1 (DGAT1) | Target's Patent Info | [1] | |
| BioCyc | Triacylglycerol biosynthesis | |||
| KEGG Pathway | Glycerolipid metabolism | |||
| Retinol metabolism | ||||
| Metabolic pathways | ||||
| Fat digestion and absorption | ||||
| Pathwhiz Pathway | Retinol Metabolism | |||
| Reactome | Acyl chain remodeling of DAG and TAG | |||
| Triglyceride Biosynthesis | ||||
| WikiPathways | Vitamin A and Carotenoid Metabolism | |||
| Statin Pathway | ||||
| Triacylglyceride Synthesis | ||||
| Glycerophospholipid biosynthesis | ||||
| Fatty acid, triacylglycerol, and ketone body metabolism | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58. | |||
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