Drug Information
Drug General Information | Top | |||
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Drug ID |
D04ENK
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Former ID |
DNC001415
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Drug Name |
TCV-309
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Synonyms |
AC1L3GRQ; LS-184311; 2-[3-(N-(2-bromo-1-propylpyridin-1-ium-4-carbonyl)anilino)propanoylamino]ethyl 3,4-dihydro-1H-isoquinoline-2-carboxylate nitrate
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Drug Type |
Small molecular drug
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Indication | Sepsis [ICD-11: 1G40-1G41; ICD-10: R57.2; ICD-9: 785.52] | Discontinued in Phase 2 | [1] | |
Structure |
Download2D MOL
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Formula |
C30H34BrN5O7
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Canonical SMILES |
CCC[N+]1=CC(=CC(=C1)Br)C(=O)N(CCC(=O)NCCOC(=O)N2CCC3=CC=CC=C3C2)C4=CC=CC=C4.[N+](=O)([O-])[O-]
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InChI |
1S/C30H33BrN4O4.NO3/c1-2-15-33-20-25(19-26(31)22-33)29(37)35(27-10-4-3-5-11-27)17-13-28(36)32-14-18-39-30(38)34-16-12-23-8-6-7-9-24(23)21-34;2-1(3)4/h3-11,19-20,22H,2,12-18,21H2,1H3;/q;-1/p+1
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InChIKey |
DVGLBKDNVHDMTD-UHFFFAOYSA-O
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CAS Number |
CAS 131311-25-6
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Platelet-activating factor receptor (PTAFR) | Target Info | Modulator | [2] |
KEGG Pathway | Calcium signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
Staphylococcus aureus infection | ||||
NetPath Pathway | IL5 Signaling Pathway | |||
Leptin Signaling Pathway | ||||
Reactome | Class A/1 (Rhodopsin-like receptors) | |||
G alpha (q) signalling events | ||||
Interferon gamma signaling | ||||
WikiPathways | GPCRs, Class A Rhodopsin-like | |||
Gastrin-CREB signalling pathway via PKC and MAPK | ||||
Small Ligand GPCRs | ||||
Interferon gamma signaling | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002130) | |||
REF 2 | Inhibitory effect of TCV-309, a novel platelet activating factor (PAF) antagonist, on endotoxin-induced disseminated intravascular coagulation in r... Thromb Res. 1993 May 15;70(4):281-93. |
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