Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04EYR
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| Former ID |
DNC000942
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| Drug Name |
Metrenperone
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| Synonyms |
Metrenperone; 81043-56-3; UNII-W1O4FV809G; W1O4FV809G; R 50 970; Metrenperona; Metrenperonum; 3-[2-[4-(4-Fluorobenzoyl)-1-piperidyl]ethyl]-2,7-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one; Metrenperonum [INN-Latin]; Metrenperona [INN-Spanish]; Sinomedol; Metrenperone [USAN:INN:BAN]; 3-(2-(4-(4-Fluorobenzoyl)-1-piperidyl)ethyl)-2,7-dimethyl-4H-pyrido(1,2-a)pyrimidin-4-one; EINECS 279-678-7; Metrenperone (USAN/INN); AC1Q4NI9; AC1L2H8G; SCHEMBL2109868; CHEMBL2104852; BDBM82382; DTXSID20230867; ZINC537997; NSC_72005; CAS_72005
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2], [3], [4] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C24H26FN3O2
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| Canonical SMILES |
CC1=CN2C(=NC(=C(C2=O)CCN3CCC(CC3)C(=O)C4=CC=C(C=C4)F)C)C=C1
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| InChI |
1S/C24H26FN3O2/c1-16-3-8-22-26-17(2)21(24(30)28(22)15-16)11-14-27-12-9-19(10-13-27)23(29)18-4-6-20(25)7-5-18/h3-8,15,19H,9-14H2,1-2H3
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| InChIKey |
AXQRPYKSPHUOGZ-UHFFFAOYSA-N
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| CAS Number |
CAS 81043-56-3
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 2 receptor (5HT2R) | Target Info | Antagonist | [1], [2], [3], [4] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Gap junction | ||||
| Serotonergic synapse | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Cardiovascular response to intravenous administration of 5-hydroxytryptamine after type-2 receptor blockade, by metrenperone, in healthy calves. Vet J. 1999 Jan;157(1):31-7. | |||
| REF 2 | Pulmonary response to intravenous administration of 5-hydroxytryptamine after type-2 receptor blockade in healthy calves. Am J Vet Res. 1993 Jan;54(1):168-73. | |||
| REF 3 | Induction of serotonin-S2 receptor blockade during early or late stage of acute respiratory distress syndrome in double-muscled calves: a comparative study. Zentralbl Veterinarmed A. 1993 May;40(4):241-8. | |||
| REF 4 | Efficiency of 5-hydroxytryptamine receptor blockade as therapeutic measure during acute respiratory distress syndrome in double-muscled cattle. Zentralbl Veterinarmed A. 1993 Apr;40(3):185-93. | |||
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