Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D04FHG
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| Former ID |
DIB020638
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| Drug Name |
PAF
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| Synonyms |
Platelet activating factor; PAF (C16); Platelet-activating factor; 74389-68-7; C16-PAF; 1-O-Hexadecyl-2-acetyl-sn-glycero-3-phosphocholine; Hag-PC; APRL; Hexadecyl-paf-acether; Platelet-activating factor C16; 1-O-Hexadecyl-platelet-activating factor; PAF C-16; 1-O-Hexadecyl-2-O-acetyl-sn-glyceryl-3-phosphorylcholine; 1-O-Hexadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine; 1-Hexadecyl-2-acetyl-glycero-3-phosphocholine; C16-PAF acether; 1-Hexadecyl-2-acetyl-sn-glycero-3-phosphocholine; Blood platelet-activating factor; platelet activating factor; [3H]PAF
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2] | |
| Structure |
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Download2D MOL
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| Formula |
C26H54NO7P
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| Canonical SMILES |
CCCCCCCCCCCCCCCCOCC(COP(=O)([O-])OCC[N+](C)(C)C)OC(=O)C
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| InChI |
1S/C26H54NO7P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21-31-23-26(34-25(2)28)24-33-35(29,30)32-22-20-27(3,4)5/h26H,6-24H2,1-5H3/t26-/m1/s1
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| InChIKey |
HVAUUPRFYPCOCA-AREMUKBSSA-N
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| CAS Number |
CAS 74389-68-7
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| PubChem Compound ID | ||||
| PubChem Substance ID |
842037, 3153230, 7889814, 7980350, 7983809, 10234619, 16102959, 24898570, 24898858, 24899040, 26754980, 26754981, 26759314, 44437041, 46508665, 50058597, 50110858, 53787114, 77374932, 91688236, 92309864, 99300778, 99302296, 103072245, 103079553, 104046560, 104251396, 104380636, 117384587, 135065116, 135651534, 135651567, 136351135, 137272099, 142259557, 144103668, 160965465, 163687537, 164347292, 179205498, 184022000, 185973898, 226757170, 241115998, 241376180, 250136828, 252156891, 252455588, 252457424, 252468864
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| ChEBI ID |
CHEBI:44811
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Platelet-activating factor receptor (PTAFR) | Target Info | Agonist | [3], [4] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Staphylococcus aureus infection | ||||
| NetPath Pathway | IL5 Signaling Pathway | |||
| Leptin Signaling Pathway | ||||
| Reactome | Class A/1 (Rhodopsin-like receptors) | |||
| G alpha (q) signalling events | ||||
| Interferon gamma signaling | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Small Ligand GPCRs | ||||
| Interferon gamma signaling | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1833). | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1831). | |||
| REF 3 | Identification of transmembrane domain residues determinant in the structure-function relationship of the human platelet-activating factor receptor by site-directed mutagenesis. J Biol Chem. 1996 Sep20;271(38):23298-303. | |||
| REF 4 | Single nucleotide polymorphism of human platelet-activating factor receptor impairs G-protein activation. J Biol Chem. 2001 Nov 16;276(46):43025-30. | |||
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