Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04HDO
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| Former ID |
DNC004909
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| Drug Name |
3-Phenethyl-2-phenyl-3H-quinazolin-4-one
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| Synonyms |
3-Phenethyl-2-phenyl-3H-quinazolin-4-one; CHEMBL180391; AC1LJAK1; Oprea1_440152; SCHEMBL5777984; MolPort-002-576-141; KANHEDFPOIQKTH-UHFFFAOYSA-N; ZINC546443; BDBM50162540; STL361550; 3-phenethyl-2-phenylquinazolin-4-one; AKOS003179499; MCULE-6975064033; 3-Phenethyl-2-phenylquinazoline-4(3H)-one; 2-phenyl-3-(2-phenylethyl)quinazolin-4(3H)-one
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C22H18N2O
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| Canonical SMILES |
C1=CC=C(C=C1)CCN2C(=NC3=CC=CC=C3C2=O)C4=CC=CC=C4
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| InChI |
1S/C22H18N2O/c25-22-19-13-7-8-14-20(19)23-21(18-11-5-2-6-12-18)24(22)16-15-17-9-3-1-4-10-17/h1-14H,15-16H2
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| InChIKey |
KANHEDFPOIQKTH-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Extracellular calcium-sensing receptor (CASR) | Target Info | Inhibitor | [1] |
| Pathway Interaction Database | E-cadherin signaling in keratinocytes | |||
| Reactome | G alpha (q) signalling events | |||
| G alpha (i) signalling events | ||||
| Class C/3 (Metabotropic glutamate/pheromone receptors) | ||||
| WikiPathways | GPCRs, Class C Metabotropic glutamate, pheromone | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 3H-Quinazolin-4-ones as a new calcilytic template for the potential treatment of osteoporosis. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1557-60. | |||
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