Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04HXU
|
|||
| Former ID |
DIB018612
|
|||
| Drug Name |
4,9-anhydro-tetrodotoxin
|
|||
| Synonyms |
4,9-anhydro-TTX; 4,9-ah-TTX
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
|
||
| Formula |
C11H16N3O7+
|
|||
| Canonical SMILES |
C(C1(C2C3C4[NH+]=C(NC35C(C1OC(C5O4)(O2)O)O)N)O)O
|
|||
| InChI |
1S/C11H15N3O7/c12-8-13-6-2-4-9(17,1-15)5-3(16)10(2,14-8)7(19-6)11(18,20-4)21-5/h2-7,15-18H,1H2,(H3,12,13,14)/p+1
|
|||
| InChIKey |
STNXQECXKDMLJK-UHFFFAOYSA-O
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Voltage-gated sodium channel alpha Nav1.6 (SCN8A) | Target Info | Blocker (channel blocker) | [2] |
| Reactome | Interaction between L1 and Ankyrins | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5730). | |||
| REF 2 | The TTX metabolite 4,9-anhydro-TTX is a highly specific blocker of the Na(v1.6) voltage-dependent sodium channel. Am J Physiol Cell Physiol. 2007 Aug;293(2):C783-9. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.