Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04PGB
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| Former ID |
DNC002704
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| Drug Name |
Gpi-1046
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| Synonyms |
186452-09-5; gpi-1046; (S)-3-(Pyridin-3-yl)propyl 1-(3,3-dimethyl-2-oxopentanoyl)pyrrolidine-2-carboxylate; CHEMBL6367; L-Proline, 1-(3,3-dimethyl-1,2-dioxopentyl)-, 3-(3-pyridinyl)propyl ester; (2S)-[3-PYRIDYL-1-PROPYL]-1-[3,3-DIMETHYL-1,2-DIOXOPENTYL]-2-PYRROLIDINECARBOXYLATE; 3-pyridin-3-ylpropyl (2S)-1-(3,3-dimethyl-2-oxopentanoyl)pyrrolidine-2-carboxylate; 3-(pyridin-3-yl)propyl (2S)-1-(3,3-dimethyl-2-oxopentanoyl)pyrrolidine-2-carboxylate; GPI; AC1L9I3R; SCHEMBL4766380; BDBM23334; CTK0I3903; DTXSID00332191
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| Drug Type |
Small molecular drug
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| Indication | Parkinson disease [ICD-11: 8A00.0; ICD-9: 332] | Terminated | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C20H28N2O4
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| Canonical SMILES |
CCC(C)(C)C(=O)C(=O)N1CCCC1C(=O)OCCCC2=CN=CC=C2
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| InChI |
1S/C20H28N2O4/c1-4-20(2,3)17(23)18(24)22-12-6-10-16(22)19(25)26-13-7-9-15-8-5-11-21-14-15/h5,8,11,14,16H,4,6-7,9-10,12-13H2,1-3H3/t16-/m0/s1
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| InChIKey |
OQAHHWOPVDDWHD-INIZCTEOSA-N
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| CAS Number |
CAS 186452-09-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
838781, 7887962, 10299710, 14754751, 14779040, 36888196, 46391853, 46506804, 50038399, 50091599, 77312207, 103164550, 104634443, 128845062, 142298025, 152134001, 160821528, 160965174, 162205224, 162479229, 163371099, 163981453, 175438115, 187071982, 204429918, 223393783, 223496137, 223554915, 230662181, 249828752, 250177554, 250195007, 252055788, 252125379
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | FK506-binding protein 1A (FKBP1A) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008349) | |||
| REF 2 | The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. | |||
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