Drug Information
Drug General Information | Top | |||
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Drug ID |
D04PGO
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Former ID |
DIB005787
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Drug Name |
MDL-28133A
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Synonyms |
Mdl 28133A; 136861-96-6; N-[4-[1-[2-(4-fluorophenyl)-2-oxo-ethyl]piperidine-4-carbonyl]phenyl]methanesulfonamide hydrochloride; Mdl-28,133A; ACMC-20mwcf; AC1L307E; CTK0H5594; DTXSID60159987; 1-(4-Fluorophenyl)-2-(4-((4-methanosulfonamidophenyl)carbonyl)-1-piperidinyl)ethanone hydrochloride; N-[4-[1-[2-(4-fluorophenyl)-2-oxoethyl]piperidine-4-carbonyl]phenyl]methanesulfonamide hydrochloride; Methanesulfonamide, N-(4-((1-(2-(4-fluorophenyl)-2-oxoethyl)-4-piperidinyl)carbonyl)phenyl)-, monohydrochloride
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Drug Type |
Small molecular drug
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Indication | Thrombosis [ICD-11: DB61-GB90; ICD-10: I80-I82] | Terminated | [1] | |
Company |
Hoechst Marion Roussel Inc
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Structure |
Download2D MOL |
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Formula |
C21H24ClFN2O4S
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Canonical SMILES |
CS(=O)(=O)NC1=CC=C(C=C1)C(=O)C2CCN(CC2)CC(=O)C3=CC=C(C=C3)F.Cl
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InChI |
1S/C21H23FN2O4S.ClH/c1-29(27,28)23-19-8-4-16(5-9-19)21(26)17-10-12-24(13-11-17)14-20(25)15-2-6-18(22)7-3-15;/h2-9,17,23H,10-14H2,1H3;1H
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InChIKey |
YVIOSUWCZDHHEI-UHFFFAOYSA-N
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CAS Number |
CAS 136861-96-6
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | 5-HT 2 receptor (5HT2R) | Target Info | Modulator | [2] |
KEGG Pathway | Calcium signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
Gap junction | ||||
Serotonergic synapse | ||||
Inflammatory mediator regulation of TRP channels |
References | Top | |||
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REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002814) | |||
REF 2 | Effects of MDL 28,133A, a 5-HT2 receptor antagonist, on platelet aggregation and coronary thrombosis in dogs. J Cardiovasc Pharmacol. 1994 Nov;24(5):761-72. |
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