Drug Information
Drug General Information | Top | |||
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Drug ID |
D04QGW
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Drug Name |
Lactam derivative 5
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Synonyms |
PMID25470667-Compound-Figure5-8
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Drug Type |
Small molecular drug
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Company |
MERCK SHARP & DOHME CORP. GRAHAM, Thomas SHEN, Dong-Ming NARGUND, Ravi, P. WU, Zhicai LIU, Wenshen
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Structure |
Download2D MOL |
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Formula |
C28H38N4O5
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Canonical SMILES |
CCCCCCCOC1=NC(=C2C(=N1)OCCN(C2=O)C3=CC=C(C=C3)C4CCC(CC4)CC(=O)O)N
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InChI |
1S/C28H38N4O5/c1-2-3-4-5-6-16-37-28-30-25(29)24-26(31-28)36-17-15-32(27(24)35)22-13-11-21(12-14-22)20-9-7-19(8-10-20)18-23(33)34/h11-14,19-20H,2-10,15-18H2,1H3,(H,33,34)(H2,29,30,31)
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InChIKey |
ZERDUDAYCJCZOG-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Diacylglycerol acyltransferase 1 (DGAT1) | Target Info | Inhibitor | [1] |
Target's Patent Info | Diacylglycerol acyltransferase 1 (DGAT1) | Target's Patent Info | [1] | |
BioCyc | Triacylglycerol biosynthesis | |||
KEGG Pathway | Glycerolipid metabolism | |||
Retinol metabolism | ||||
Metabolic pathways | ||||
Fat digestion and absorption | ||||
Pathwhiz Pathway | Retinol Metabolism | |||
Reactome | Acyl chain remodeling of DAG and TAG | |||
Triglyceride Biosynthesis | ||||
WikiPathways | Vitamin A and Carotenoid Metabolism | |||
Statin Pathway | ||||
Triacylglyceride Synthesis | ||||
Glycerophospholipid biosynthesis | ||||
Fatty acid, triacylglycerol, and ketone body metabolism |
References | Top | |||
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REF 1 | Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58. |
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