Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D04QIA
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| Former ID |
DNC009741
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| Drug Name |
Ro-66-1168
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| Synonyms |
Ro-66-1168; CHEMBL1276275; 304025-53-4; Acetamide,N-[2-[3,4-dihydro-7-[[[(3R,4R)-4-[4-[3-[(2-methoxyphenyl)methoxy]propoxy]phenyl]-3-piperidinyl]oxy]methyl]-1(2H)-quinolinyl]ethyl]-; SCHEMBL5556763; YKAHCPSTICMMFK-ILFWFZRHSA-N; ZINC3985435; BDBM50330345; KB-74440; N-[2-[7-[[4beta-[4-[3-(2-Methoxybenzyloxy)propoxy]phenyl]piperidine-3alpha-yloxy]methyl]-1,2,3,4-tetrahydroquinoline-1-yl]ethyl]acetamide
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C36H47N3O5
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| Canonical SMILES |
CC(=O)NCCN1CCCC2=C1C=C(C=C2)COC3CNCCC3C4=CC=C(C=C4)OCCCOCC5=CC=CC=C5OC
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| InChI |
1S/C36H47N3O5/c1-27(40)38-18-20-39-19-5-8-30-11-10-28(23-34(30)39)25-44-36-24-37-17-16-33(36)29-12-14-32(15-13-29)43-22-6-21-42-26-31-7-3-4-9-35(31)41-2/h3-4,7,9-15,23,33,36-37H,5-6,8,16-22,24-26H2,1-2H3,(H,38,40)/t33-,36+/m1/s1
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| InChIKey |
YKAHCPSTICMMFK-ILFWFZRHSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Angiotensinogenase renin (REN) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Renin-angiotensin system | |||
| Pathwhiz Pathway | Angiotensin Metabolism | |||
| Reactome | Metabolism of Angiotensinogen to Angiotensins | |||
| WikiPathways | ACE Inhibitor Pathway | |||
| Metabolism of Angiotensinogen to Angiotensins | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Design and preparation of potent, nonpeptidic, bioavailable renin inhibitors. J Med Chem. 2009 Jun 25;52(12):3689-702. | |||
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