Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04QJD
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| Former ID |
DAP000643
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| Drug Name |
Valaciclovir
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| Synonyms |
Talavir; VACV; ValACV; Valacyclovir; Virval; Zelitrex; Valaciclovir Hcl; Valacyclover Hydrochloric; Valacyclover Hydrochloride; BW256U87; TBB067866; Acyclovir-valine; BW-256U; Valaciclovir (INN); Valaciclovir [INN:BAN]; Valaciclovir, Valtrex; Valtrex (TN); Zelitrex (TN); Valacyclovir, (L)-isomer; L-Valine ester with 9-((2-hydroxyethoxy)methyl)guanine; L-Valine, 2-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)ethyl ester; L-valine, 2-[(2-amino-1,6-dihydro-6-oxo-9 H-purin-9-yl)methoxy]ethyl ester, monohydrochloride; 2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]ethyl L-valinate; 2-[(2-amino-6-oxo-3H-purin-9-yl)methoxy]ethyl (2S)-2-amino-3-methylbutanoate; 2-{[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methyl]oxy}ethyl L-valinate
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| Drug Type |
Small molecular drug
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| Indication | Virus infection [ICD-11: 1A24-1D9Z] | Approved | [1], [2] | |
| Therapeutic Class |
Antiviral Agents
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| Company |
GlaxoSmithKline
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| Structure |
 |
Download2D MOL |
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| Formula |
C13H20N6O4
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| Canonical SMILES |
CC(C)C(C(=O)OCCOCN1C=NC2=C1N=C(NC2=O)N)N
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| InChI |
1S/C13H20N6O4/c1-7(2)8(14)12(21)23-4-3-22-6-19-5-16-9-10(19)17-13(15)18-11(9)20/h5,7-8H,3-4,6,14H2,1-2H3,(H3,15,17,18,20)/t8-/m0/s1
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| InChIKey |
HDOVUKNUBWVHOX-QMMMGPOBSA-N
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| CAS Number |
CAS 124832-26-4
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| PubChem Compound ID | ||||
| PubChem Substance ID |
626316, 7980871, 12014356, 14718342, 14777186, 14801572, 14850688, 14850689, 14874889, 15940044, 29215498, 43118121, 46508197, 47589092, 48416691, 50062212, 56422581, 57314102, 78076275, 85279714, 85789653, 89736139, 92309076, 92710527, 96025347, 99775325, 103440109, 104048282, 104178841, 104321602, 117583422, 118313436, 124800881, 126631789, 126658129, 126682447, 128045545, 131905333, 134213320, 134221757, 134337933, 135030189, 135659820, 137005923, 137005924, 142590832, 160963922, 162782405, 163231563, 163621098
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| ChEBI ID |
CHEBI:35854
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| ADReCS Drug ID | BADD_D02323 ; BADD_D02324 ; BADD_D02424 | |||
| SuperDrug ATC ID |
J05AB11
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| SuperDrug CAS ID |
cas=124832264
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Herpes simplex virus DNA polymerase UL30 (HSV UL30) | Target Info | Inhibitor | [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4824). | |||
| REF 2 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
| REF 3 | Extensive oral shedding of human herpesvirus 8 in a renal allograft recipient. Oral Microbiol Immunol. 2009 Apr;24(2):109-15. | |||
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