Drug Information
Drug General Information | Top | |||
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Drug ID |
D04QPK
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Former ID |
DNC004700
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Drug Name |
3-[4-Fluoro-indan-(1E)-ylidenemethyl]-pyridine
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Synonyms |
(3-Pyridylmethylene)indane 24a; SCHEMBL4221248; SCHEMBL4221241; AC1O705H; CHEMBL366490; BDBM8607; 3-[(E)-(4-fluoro-2,3-dihydroinden-1-ylidene)methyl]pyridine
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C15H12FN
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Canonical SMILES |
C1CC2=C(C1=CC3=CN=CC=C3)C=CC=C2F
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InChI |
1S/C15H12FN/c16-15-5-1-4-13-12(6-7-14(13)15)9-11-3-2-8-17-10-11/h1-5,8-10H,6-7H2/b12-9+
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InChIKey |
JKDSUQNXZNYUED-FMIVXFBMSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Aromatase (CYP19A1) | Target Info | Inhibitor | [1] |
Steroid 11-beta-hydroxylase (CYP11B1) | Target Info | Inhibitor | [1] | |
BioCyc | Superpathway of steroid hormone biosynthesis | |||
Glucocorticoid biosynthesis | ||||
Mineralocorticoid biosynthesis | ||||
Estradiol biosynthesis II | ||||
Estradiol biosynthesis I | ||||
KEGG Pathway | Steroid hormone biosynthesis | |||
Metabolic pathways | ||||
Ovarian steroidogenesis | ||||
NetPath Pathway | FSH Signaling Pathway | |||
Panther Pathway | Androgen/estrogene/progesterone biosynthesis | |||
Pathwhiz Pathway | Steroidogenesis | |||
Androgen and Estrogen Metabolism | ||||
Reactome | Glucocorticoid biosynthesis | |||
Endogenous sterols | ||||
WikiPathways | Metapathway biotransformation | |||
Oxidation by Cytochrome P450 | ||||
Metabolism of steroid hormones and vitamin D | ||||
Corticotropin-releasing hormone | ||||
Tryptophan metabolism | ||||
Ovarian Infertility Genes | ||||
FSH signaling pathway | ||||
Integrated Breast Cancer Pathway | ||||
Phase 1 - Functionalization of compounds |
References | Top | |||
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REF 1 | Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. |
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