Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04SQY
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| Former ID |
DIB019715
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| Drug Name |
deoxycorticosterone
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| Synonyms |
11-deoxycorticosterone; 21-hydroxyprogesterone
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C21H30O3
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| Canonical SMILES |
CC12CCC3C(C1CCC2C(=O)CO)CCC4=CC(=O)CCC34C
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| InChI |
1S/C21H30O3/c1-20-9-7-14(23)11-13(20)3-4-15-16-5-6-18(19(24)12-22)21(16,2)10-8-17(15)20/h11,15-18,22H,3-10,12H2,1-2H3/t15-,16-,17-,18+,20-,21-/m0/s1
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| InChIKey |
ZESRJSPZRDMNHY-YFWFAHHUSA-N
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| CAS Number |
CAS 64-85-7
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| PubChem Compound ID | ||||
| PubChem Substance ID |
6081, 841768, 855538, 3136426, 6435811, 6436728, 7885076, 8144739, 8153870, 11466985, 11468105, 11486839, 12146618, 14753185, 24702312, 24894056, 26737269, 29225165, 47275752, 47573556, 48094736, 48243599, 49699039, 49960527, 50103900, 53788533, 56412749, 56424139, 57323229, 57392893, 80433608, 81062004, 81093225, 85165316, 85787368, 92125920, 92298674, 96024489, 103556916, 103914536, 104311286, 109658567, 121363591, 124801181, 125003832, 126522953, 126651375, 127337403, 127337404, 127342267
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| ChEBI ID |
CHEBI:16973
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glucocorticoid receptor messenger RNA (GCR mRNA) | Target Info | Agonist | [2] |
| Mineralocorticoid receptor (MR) | Target Info | Agonist | [3] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Aldosterone-regulated sodium reabsorption | ||||
| NetPath Pathway | IL2 Signaling Pathway | |||
| TCR Signaling Pathway | ||||
| Pathwhiz Pathway | Kidney Function | |||
| Pathway Interaction Database | Regulation of nuclear SMAD2/3 signaling | |||
| Signaling events mediated by HDAC Class II | ||||
| FOXA2 and FOXA3 transcription factor networks | ||||
| Glucocorticoid receptor regulatory network | ||||
| Regulation of Androgen receptor activity | ||||
| AP-1 transcription factor network | ||||
| Reactome | BMAL1:CLOCK,NPAS2 activates circadian gene expression | |||
| WikiPathways | Serotonin Receptor 4/6/7 and NR3C Signaling | |||
| SIDS Susceptibility Pathways | ||||
| Endoderm Differentiation | ||||
| Hair Follicle Development: Cytodifferentiation (Part 3 of 3) | ||||
| Adipogenesis | ||||
| Circadian Clock | ||||
| Nuclear Receptors | ||||
| ACE Inhibitor Pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2871). | |||
| REF 2 | Functional probing of the human glucocorticoid receptor steroid-interacting surface by site-directed mutagenesis. Gln-642 plays an important role in steroid recognition and binding. J Biol Chem. 2000Jun 23;275(25):19041-9. | |||
| REF 3 | Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands. Eur J Pharmacol. 1993 Oct 15;247(2):145-54. | |||
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