Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04USC
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| Former ID |
DAP001379
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| Drug Name |
Ergotidine
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| Synonyms |
Eramin; Ergamine; Histamine; Histaminum; Istamina; Theramine; Free histamine; Histamine Base; Histamine [USAN]; Istamina [Italian]; H7125_SIGMA; [3H]histamine; ALBB-005968; Beta-Aminoethylglyoxaline; Beta-Aminoethylimidazole; Beta-aminothethylglyoxaline; Histamine (DCF); Histamine, Free Base; Histaminum (TN); L-histamine; ZERO/004089; Imidazole-4-ethylamine; Beta-Imidazolyl-4-ethylamine; F411C768-A159-4FC0-A195-291A08BB03AA; 1H-Imidazole-4-ethanamine; 1H-Imidazole-5-ethanamine; 2-(1H-Imidazol-4-yl)ethanamine; 2-(1H-imidazol-4-yl)ethan-1-amine; 2-(1H-imidazol-5-yl)ethanamine; 2-(3H-Imidazol-4-yl)-ethylamine; 2-(4-Imidazolyl)ethylamine; 2-Imidazol-4-ylethylamine; 2-[4-Imidazolyl]ethylamine; 4-(2-Aminoethyl)-1H-imidazole; 4-Imidazoleethylamine; 5-Imidazoleethylamine
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| Drug Type |
Small molecular drug
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| Indication | Respiratory allergy [ICD-11: 4A80; ICD-10: J39.3] | Approved | [1], [2], [3] | |
| Therapeutic Class |
Antiallergic Agents
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| Structure |
 |
Download2D MOL |
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| Formula |
C5H9N3
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| Canonical SMILES |
C1=C(NC=N1)CCN
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| InChI |
1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
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| InChIKey |
NTYJJOPFIAHURM-UHFFFAOYSA-N
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| CAS Number |
CAS 51-45-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
3678, 91789, 609692, 822767, 824161, 853773, 3156918, 3221723, 3727072, 5065169, 5186157, 6436474, 7735853, 7888228, 7979989, 8139979, 8143824, 8150782, 10524836, 11108702, 11111275, 11120367, 11120855, 11121343, 11121734, 11122214, 11335483, 11360722, 11362871, 11363739, 11365433, 11366301, 11367995, 11368863, 11370953, 11370954, 11371444, 11373596, 11374718, 11376157, 11377025, 11461694, 11484465, 11488481, 11490268, 11492775, 11494659, 11537616, 15146444, 16080673
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| ChEBI ID |
CHEBI:18295
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| ADReCS Drug ID | BADD_D01071 | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Histamine H1 receptor (H1R) | Target Info | Agonist | [2] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| Panther Pathway | Histamine H1 receptor mediated signaling pathway | |||
| Reactome | Histamine receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | Monoamine GPCRs | |||
| GPCRs, Class A Rhodopsin-like | ||||
| IL-4 Signaling Pathway | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1247). | |||
| REF 2 | Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. Mol Pharmacol. 2001 Mar;59(3):420-6. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
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