Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D04VMT
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| Former ID |
DAP000372
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| Drug Name |
Sotalol
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| Synonyms |
Sotalolum; Darob mite; Sotalol Monohydrochloride; Beta-Cardone; Betapace (TN); Betapace AF (TN); Darob mite (TN); MJ-1999; Sotacor (TN); Sotalex (TN); Sotalol (INN); Sotalol [INN:BAN]; Sotalolum [INN-Latin]; D,l-Sotalol; N-[4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl]methanesulfonamide; N-(4-{1-hydroxy-2-[(1-methylethyl)amino]ethyl}phenyl)methanesulfonamide; N-{4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl}methanesulfonamide; Methanesulfonamide, N-(4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)phenyl)-(9CI); 4'-(1-Hydroxy-2-(isopropylamino)ethyl)methane sulfonanilide; 4'-(1-Hydroxy-2-isopropylaminoethyl)methanesulfonanilid
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| Drug Type |
Small molecular drug
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| Indication | Sinus rhythm disorder [ICD-11: BC9Y; ICD-9: 427] | Approved | [1], [2] | |
| Therapeutic Class |
Antiarrhythmic Agents
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| Company |
Bristol-Myers Squibb
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| Structure |
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Download2D MOL |
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| Formula |
C12H20N2O3S
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| Canonical SMILES |
CC(C)NCC(C1=CC=C(C=C1)NS(=O)(=O)C)O
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| InChI |
1S/C12H20N2O3S/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17/h4-7,9,12-15H,8H2,1-3H3
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| InChIKey |
ZBMZVLHSJCTVON-UHFFFAOYSA-N
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| CAS Number |
CAS 3930-20-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9517, 3221867, 5612028, 7980639, 8153233, 10521436, 11466994, 11468114, 11486628, 14775037, 26751989, 29224308, 46505012, 47730756, 47879636, 48029202, 48029203, 48253453, 48416548, 49699392, 49991262, 50104666, 53790038, 56413050, 57288838, 57322681, 80811639, 85220240, 85788914, 90341280, 92308885, 92717147, 96025210, 103168744, 104171235, 104308703, 118314017, 124750203, 124881382, 124881383, 124881384, 125349604, 126622467, 128364869, 129878952, 134337682, 134985209, 135610135, 137100765, 142466945
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| ChEBI ID |
CHEBI:63622
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| ADReCS Drug ID | BADD_D02060 ; BADD_D02061 | |||
| SuperDrug ATC ID |
C07AA07
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| SuperDrug CAS ID |
cas=003930209
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides fragilis ATCC43859
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Sotalol can be metabolized by Bacteroides fragilis ATCC43859 (log2FC = -0.907; p = 0.014). | |||
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Studied Microbe: Bacteroides fragilis HMW 610
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|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Sotalol can be metabolized by Bacteroides fragilis HMW 610 (log2FC = -0.896; p = 0.039). | |||
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Studied Microbe: Bacteroides fragilis HMW 615
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Sotalol can be metabolized by Bacteroides fragilis HMW 615 (log2FC = -0.826; p = 0.033). | |||
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Studied Microbe: Bacteroides fragilis str. 3397 T10
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|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Sotalol can be metabolized by Bacteroides fragilis str. 3397 T10 (log2FC = -0.701; p = 0.005). | |||
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Studied Microbe: Bacteroides fragilis str. DS-208
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Sotalol can be metabolized by Bacteroides fragilis str. DS-208 (log2FC = -0.629; p = 0.021). | |||
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Studied Microbe: Bacteroides ovatus ATCC 8483
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|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Sotalol can be metabolized by Bacteroides ovatus ATCC 8483 (log2FC = -0.629; p = 0.019). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 7330
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|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Sotalol can be metabolized by Bacteroides thetaiotaomicron 7330 (log2FC = -0.681; p = 0.009). | |||
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Studied Microbe: Bacteroides thetaiotaomicron VPI-5482
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|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Sotalol can be metabolized by Bacteroides thetaiotaomicron VPI-5482 (log2FC = -0.545; p = 0.044). | |||
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Studied Microbe: Bacteroides uniformis ATCC 8492
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|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Sotalol can be metabolized by Bacteroides uniformis ATCC 8492 (log2FC = -0.529; p = 0.034). | |||
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Studied Microbe: Pretovella copri DSM 18205
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|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Sotalol can be metabolized by Pretovella copri DSM 18205 (log2FC = -0.371; p = 0.042). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adrenergic receptor beta-1 (ADRB1) | Target Info | Antagonist | [4] |
| KEGG Pathway | Calcium signaling pathway | |||
| cGMP-PKG signaling pathway | ||||
| cAMP signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| Endocytosis | ||||
| Adrenergic signaling in cardiomyocytes | ||||
| Gap junction | ||||
| Salivary secretion | ||||
| Dilated cardiomyopathy | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Beta1 adrenergic receptor signaling pathway | ||||
| Pathwhiz Pathway | Muscle/Heart Contraction | |||
| Reactome | Adrenoceptors | |||
| G alpha (s) signalling events | ||||
| WikiPathways | Monoamine GPCRs | |||
| Calcium Regulation in the Cardiac Cell | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| Endothelin Pathways | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7297). | |||
| REF 2 | New antiarrhythmic agents for atrial fibrillation and atrial flutter. Expert Opin Emerg Drugs. 2005 May;10(2):311-22. | |||
| REF 3 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
| REF 4 | beta(2)-adrenoceptors are critical for antidepressant treatment of neuropathic pain. Ann Neurol. 2009 Feb;65(2):218-25. | |||
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