Drug Information
Drug General Information | Top | |||
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Drug ID |
D04WFD
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Former ID |
DAP001152
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Drug Name |
Nortriptyline
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Synonyms |
Acetexa; Allegron; Altilev; Ateben; Avantyl; Aventyl; Demethylamitriptylene; Demethylamitriptyline; Demethylamitryptyline; Desitriptilina; Desitriptyline; Desmethylamitriptylin; Desmethylamitriptyline; Lumbeck; Noramitriptyline; Noritren; Nortrilen; Nortriptilina; Nortriptylinum; Nortryptiline; Nortryptyline; Pamelor; Psychostyl; Sensaval; Sesaval; Vividyl; AVENTYL HCL; Nortriptilina [DCIT]; Nortriptylene hydrochloride; Pamelor hydrochloride; Sensival Ventyl; NCI169453; Allegron (TN); Aventyl (TN); Norpress (TN); Nortrilen (TN); Nortriptyline (INN); Nortriptyline [INN:BAN]; Nortriptylinum [INN-Latin]; Pamelor (TN); Sensoval (TN); N-Methyl-3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-yliden)propylamin; (2)10,11-Dihydro-N-methyl-5H-dibenzo[a,d]cycloheptene-.delta.5.gamma.-propylamine; 10,11-Dihydro-5-(3-methylaminopropylidene)-5H-dibenzo(a,d)(1,4)cycloheptene; 10,11-Dihydro-N-methyl-5H-dibenzo(a,d)cycloheptene-delta(5,gamma)-propylamine; 10,11-dihydro-N-methyl-5H-dibenzo[a,d]cycloheptene-Delta(5,gamma)-propylamine; 3-(10,11-Dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N-methylpropylamine; 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine; 3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N-methylpropan-1-amine; 5-(3-(Methylamino)propylidene)dibenzo(a,e)cyclohepta(1,5)diene; 5-(3-Methylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene; 5-(alpha-Methylaminopropylidene)dibenzo(a,d)cyclohepta(1,4)diene
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Drug Type |
Small molecular drug
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Indication | Depression [ICD-11: 6A70-6A7Z; ICD-9: 311] | Approved | [1], [2] | |
Therapeutic Class |
Antidepressants
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Structure |
Download2D MOL |
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Formula |
C19H21N
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Canonical SMILES |
CNCCC=C1C2=CC=CC=C2CCC3=CC=CC=C31
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InChI |
1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-11,20H,6,12-14H2,1H3
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InChIKey |
PHVGLTMQBUFIQQ-UHFFFAOYSA-N
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CAS Number |
CAS 72-69-5
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PubChem Compound ID | ||||
PubChem Substance ID |
9483, 798361, 4253930, 6577383, 7849631, 7980173, 8149453, 8152799, 10319679, 10534016, 11110653, 11110654, 11335326, 11360565, 11363935, 11366497, 11369059, 11371711, 11374009, 11377221, 11405749, 11451840, 11458278, 11460107, 11461537, 11466282, 11467402, 11484829, 11486023, 11488813, 11490342, 11492270, 11494855, 14799043, 26611847, 26652424, 26679863, 26747092, 26747093, 29214861, 29223634, 46507783, 47216645, 47216646, 47291002, 47515179, 47515180, 47662126, 47885274, 47959587
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ChEBI ID |
CHEBI:7640
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ADReCS Drug ID | BADD_D01588 ; BADD_D01589 | |||
SuperDrug ATC ID |
N06AA10
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SuperDrug CAS ID |
cas=000072695
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Target and Pathway | Top | |||
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Target(s) | Serotonin transporter (SERT) | Target Info | Modulator | [3] |
KEGG Pathway | Serotonergic synapse | |||
NetPath Pathway | TCR Signaling Pathway | |||
Panther Pathway | 5HT1 type receptor mediated signaling pathway | |||
5HT2 type receptor mediated signaling pathway | ||||
5HT3 type receptor mediated signaling pathway | ||||
5HT4 type receptor mediated signaling pathway | ||||
WikiPathways | Monoamine Transport | |||
SIDS Susceptibility Pathways | ||||
NRF2 pathway | ||||
Synaptic Vesicle Pathway | ||||
Serotonin Transporter Activity |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2404). | |||
REF 2 | Emerging treatments for depression. Expert Opin Pharmacother. 2006 Dec;7(17):2323-39. | |||
REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. |
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