Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D04XZE
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| Former ID |
DNC001582
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| Drug Name |
NS-7
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| Synonyms |
(3r)-3-Cyclopentyl-6-Methyl-7-[(4-Methylpiperazin-1-Yl)sulfonyl]-3,4-Dihydro-2h-1,2-Benzothiazine 1,1-Dioxide; DB08305; NS7
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| Drug Type |
Small molecular drug
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| Indication | Nerve injury [ICD-11: ND56.4; ICD-10: T14.4] | Phase 2 | [1] | |
| Therapeutic Class |
Analgesics
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| Structure |
 |
Download2D MOL
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| Formula |
C21H29ClFN3O
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| Canonical SMILES |
CC1=NC(=CC(=N1)OCCCCCN2CCCCC2)C3=CC=C(C=C3)F.Cl
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| InChI |
1S/C21H28FN3O.ClH/c1-17-23-20(18-8-10-19(22)11-9-18)16-21(24-17)26-15-7-3-6-14-25-12-4-2-5-13-25;/h8-11,16H,2-7,12-15H2,1H3;1H
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| InChIKey |
VLYZLIWXMLUPLD-UHFFFAOYSA-N
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| CAS Number |
CAS 178429-67-9
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Sodium channel unspecific (NaC) | Target Info | Modulator | [1] |
| KEGG Pathway | Dopaminergic synapse | |||
| Reactome | Interaction between L1 and Ankyrins | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Preferential inhibition by a novel Na(+)/Ca(2+) channel blocker NS-7 of severe to mild hypoxic injury in rat cerebrocortical slices: A possible involvement of a highly voltage-dependent blockade of Ca(2+) channel. J Pharmacol Exp Ther. 2000 May;293(2):522-9. | |||
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