Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D04YNW
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| Former ID |
DNC000350
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| Drug Name |
BRL 52537 hydrochloride
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| Synonyms |
2-(3,4-Dichlorophenyl)-1-(2-(pyrrolidin-1-ylmethyl)piperidin-1-yl)ethanone hydrochloride; 130497-33-5; 112282-24-3; BRL 52537; AK-57392; (+/-)-1-(3,4-Dichlorophenyl)acetyl-2-(1-pyrrolidinyl)methylpiperidine hydrochloride; 2-(3,4-DICHLOROPHENYL)-1-(2-(PYRROLIDIN-1-YLMETHYL)PIPERIDIN-1-YL)ETHANONE HCL; SR-01000076141; EU-0101141; BRL-52537 hydrochloride; Brl 52537 HCl; MLS002153457; SCHEMBL8435659; CHEMBL1256835; KS-00000FTT; CTK8C4721; DTXSID00462129; MolPort-003-940-484; BCP21081; EBD29079
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C18H25Cl3N2O
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| Canonical SMILES |
C1CCN(C(C1)CN2CCCC2)C(=O)CC3=CC(=C(C=C3)Cl)Cl.Cl
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| InChI |
1S/C18H24Cl2N2O.ClH/c19-16-7-6-14(11-17(16)20)12-18(23)22-10-2-1-5-15(22)13-21-8-3-4-9-21;/h6-7,11,15H,1-5,8-10,12-13H2;1H
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| InChIKey |
NGVLSOWJSUUYDE-UHFFFAOYSA-N
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| CAS Number |
CAS 130497-33-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
16404595, 17405697, 23480767, 24278716, 42394690, 50107062, 52415579, 53778247, 56463467, 91703265, 92303331, 123100674, 134339796, 135372722, 135698168, 136379554, 152049710, 152212294, 152254728, 152344428, 160840400, 162011471, 163099635, 163565095, 172093635, 172096435, 172870784, 174473416, 180672643, 184594793, 185981674, 204420262, 223378425, 223434978, 233947597, 241181833, 242060373, 249741609, 249847349, 250179619, 250201211, 252033978, 252215065, 252315895, 252430933
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Opioid receptor kappa (OPRK1) | Target Info | Agonist | [1] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
| Opioid prodynorphin pathway | ||||
| Reactome | Peptide ligand-binding receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Peptide GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Kappa-opioid receptor selectivity for ischemic neuroprotection with BRL 52537 in rats. Anesth Analg. 2003 Dec;97(6):1776-83. | |||
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