Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D05BII
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| Former ID |
DIB008845
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| Drug Name |
Ancrod
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| Synonyms |
Arvin; Arwin; Venacil; Viprinex; Agkistrodon rhodostoma venom proteinase; Agkistrodon serine proteinase; Snake venom, Knoll
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| Indication | Blood forming organ disorder [ICD-11: JB64.1; ICD-10: O99.1] | Phase 3 | [1] | |
| Company |
Knoll GmbH; Neurobiological Technologies
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Vitamin K-dependent protein C (PROC) | Target Info | Modulator | [2] |
| KEGG Pathway | Complement and coagulation cascades | |||
| Panther Pathway | Blood coagulation | |||
| Pathway Interaction Database | Beta2 integrin cell surface interactions | |||
| Reactome | Intrinsic Pathway of Fibrin Clot Formation | |||
| Common Pathway of Fibrin Clot Formation | ||||
| Gamma-carboxylation of protein precursors | ||||
| Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus | ||||
| Removal of aminoterminal propeptides from gamma-carboxylated proteins | ||||
| Cell surface interactions at the vascular wall | ||||
| WikiPathways | Complement and Coagulation Cascades | |||
| PTM: gamma carboxylation, hypusine formation and arylsulfatase activation | ||||
| Formation of Fibrin Clot (Clotting Cascade) | ||||
| Cell surface interactions at the vascular wall | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00141011) Ancrod (Viprinex for the Treatment of Acute, Ischemic Stroke. U.S. National Institutes of Health. | |||
| REF 2 | Ancrod (Arvin) as an alternative to heparin anticoagulation for cardiopulmonary bypass. Anesthesiology. 1989 Dec;71(6):870-7. | |||
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