Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D05CBS
|
|||
| Drug Name |
PMID25435285-Compound-37
|
|||
| Drug Type |
Small molecular drug
|
|||
| Company |
F. HOFFMANN-LA ROCHE AG GATTI MCARTHUR, Silvia GOETSCHI, Erwin WICHMANN, Juergen WOLTERING, Thomas Johannes
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C25H17F6N3
|
|||
| Canonical SMILES |
CC1=CC(=CC(=N1)C)C2=CC(=CC=C2)C3=NC(=CC(=N3)C(F)(F)F)C4=CC=C(C=C4)C(F)(F)F
|
|||
| InChI |
1S/C25H17F6N3/c1-14-10-19(11-15(2)32-14)17-4-3-5-18(12-17)23-33-21(13-22(34-23)25(29,30)31)16-6-8-20(9-7-16)24(26,27)28/h3-13H,1-2H3
|
|||
| InChIKey |
UTZMRRRZFDOYFQ-UHFFFAOYSA-N
|
|||
| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Metabotropic glutamate receptor 2 (mGluR2) | Target Info | Antagonist | [1] |
| Target's Patent Info | Metabotropic glutamate receptor 2 (mGluR2) | Target's Patent Info | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Glutamatergic synapse | ||||
| Cocaine addiction | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
| Ionotropic glutamate receptor pathway | ||||
| Metabotropic glutamate receptor group II pathway | ||||
| Reactome | G alpha (i) signalling events | |||
| Class C/3 (Metabotropic glutamate/pheromone receptors) | ||||
| WikiPathways | GPCRs, Class C Metabotropic glutamate, pheromone | |||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.