Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D05COL
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| Former ID |
DNC006846
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| Drug Name |
SALVINORIN B
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| Synonyms |
Salvinorin B; CHEMBL424698; 92545-30-7; Divinorin B; (-)-Salvinorin B; SCHEMBL3144611; DTXSID50465988; BLTMVAIOAAGYAR-CEFSSPBYSA-N; (2S,4aR,6aR,7R,9S,10aS,10bR)-2-(3-Furanyl)dodecahydro-9-hydroxy-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic Acid Methyl Ester; ZINC15449154; BDBM50189136; Salvinorin B, > =93.0% (HPLC); AKOS027326793; NCGC00181787-01; Salvinorin B solution, 1.0 mg/mL in acetonitrile: water (9:1), ampule of 1 mL, certified reference material; [2S-(2; A,4a; A,6a; A,9; A,10a; A,10b
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C21H26O7
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| Canonical SMILES |
CC12CCC3C(=O)OC(CC3(C1C(=O)C(CC2C(=O)OC)O)C)C4=COC=C4
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| InChI |
1S/C21H26O7/c1-20-6-4-12-19(25)28-15(11-5-7-27-10-11)9-21(12,2)17(20)16(23)14(22)8-13(20)18(24)26-3/h5,7,10,12-15,17,22H,4,6,8-9H2,1-3H3/t12-,13-,14-,15-,17-,20-,21-/m0/s1
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| InChIKey |
BLTMVAIOAAGYAR-CEFSSPBYSA-N
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| CAS Number |
CAS 92545-30-7
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Opioid receptor kappa (OPRK1) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
| Opioid prodynorphin pathway | ||||
| Reactome | Peptide ligand-binding receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Peptide GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Herkinorin analogues with differential beta-arrestin-2 interactions. J Med Chem. 2008 Apr 24;51(8):2421-31. | |||
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