Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D05EPM
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| Former ID |
DAP000512
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| Drug Name |
Ethotoin
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| Synonyms |
Accenon; Ethotoine; Ethotoinum; Etotoina; Peganone; Pegoanone; Abbott brand of ethotoin; Accenon (TN); Ethotoine [INN-French]; Ethotoinum [INN-Latin]; Etotoina [INN-Spanish]; Peganone (TN); Ethotoin [INN:BAN:JAN]; Ethotoin (JAN/USP/INN); (+-)-3-Ethyl-5-phenylhydantoin; 1-Ethyl-2,5-dioxo-4-phenylimidazolidine; 3-Ethyl-5-phenyl-2,4-imidazolidinedione; 3-Ethyl-5-phenylhydantoin; 3-Ethyl-5-phenylimidazolidin-2,4-dione; 3-ethyl-5-phenylimidazolidine-2,4-dione
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| Drug Type |
Small molecular drug
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| Indication | Complex partial seizure [ICD-11: 8A68.0; ICD-9: 345.4] | Approved | [1], [2] | |
| Therapeutic Class |
Anticonvulsants
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| Company |
Ovation Pharmaceuticals
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| Structure |
 |
Download2D MOL |
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| Formula |
C11H12N2O2
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| Canonical SMILES |
CCN1C(=O)C(NC1=O)C2=CC=CC=C2
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| InChI |
1S/C11H12N2O2/c1-2-13-10(14)9(12-11(13)15)8-6-4-3-5-7-8/h3-7,9H,2H2,1H3,(H,12,15)
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| InChIKey |
SZQIFWWUIBRPBZ-UHFFFAOYSA-N
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| CAS Number |
CAS 86-35-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
10041, 5235098, 7847773, 7979201, 8152092, 10537073, 11466724, 11467844, 11486508, 15463341, 29222430, 46504521, 47314288, 47464128, 47834450, 47834451, 48134126, 48415979, 49699145, 49977230, 50124114, 50283352, 56459446, 56463534, 57321709, 92125817, 99437357, 103303661, 103913707, 104303083, 121363488, 124800256, 126407581, 134337805, 134970936, 137008519, 137260962, 140085433, 144076267, 144203934, 145259068, 160964097, 175611111, 177513114, 178103758, 178126524, 179116676, 221672900, 225144304, 226420792
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| ChEBI ID |
CHEBI:4888
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| ADReCS Drug ID | BADD_D00847 | |||
| SuperDrug ATC ID |
N03AB01
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| SuperDrug CAS ID |
cas=000086351
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Voltage-gated sodium channel alpha Nav1.5 (SCN5A) | Target Info | Blocker | [3] |
| KEGG Pathway | Adrenergic signaling in cardiomyocytes | |||
| Pathwhiz Pathway | Muscle/Heart Contraction | |||
| Reactome | Interaction between L1 and Ankyrins | |||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Cardiac Progenitor Differentiation | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7183). | |||
| REF 2 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 010841. | |||
| REF 3 | How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | |||
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