Drug Information
Drug General Information | Top | |||
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Drug ID |
D05ERF
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Former ID |
DNC012673
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Drug Name |
TQX-173
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Synonyms |
TQX-173; CHEMBL267276; SCHEMBL2038719; BDBM50092637; 7-Chloro-4-oxo-8-[1,2,4]triazol-4-yl-4,5-dihydro-[1,2,4]triazolo[1,5-a]quinoxaline-2-carboxylic acid
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C12H6ClN7O3
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Canonical SMILES |
C1=C2C(=CC(=C1Cl)N3C=NN=C3)N4C(=NC(=N4)C(=O)O)C(=O)N2
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InChI |
1S/C12H6ClN7O3/c13-5-1-6-8(2-7(5)19-3-14-15-4-19)20-10(11(21)16-6)17-9(18-20)12(22)23/h1-4H,(H,16,21)(H,22,23)
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InChIKey |
QYMZRTSHYZACQA-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Glutamate receptor ionotropic kainate 1 (GRIK1) | Target Info | Inhibitor | [1] |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Glutamatergic synapse | ||||
Panther Pathway | Huntington disease | |||
Ionotropic glutamate receptor pathway | ||||
Metabotropic glutamate receptor group III pathway | ||||
Metabotropic glutamate receptor group I pathway | ||||
WikiPathways | Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell |
References | Top | |||
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REF 1 | Synthesis, ionotropic glutamate receptor binding affinity, and structure-activity relationships of a new set of 4,5-dihydro-8-heteroaryl-4-oxo-1,2,... J Med Chem. 2001 Sep 13;44(19):3157-65. |
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