Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D05FYA
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| Former ID |
DNC001435
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| Drug Name |
Thioperamide
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| Synonyms |
Thioperamide; 106243-16-7; Thioperamide maleate; MR 12842; UNII-II4319BWUI; 1-Piperidinecarbothioamide, N-cyclohexyl-4-(1H-imidazol-4-yl)-; II4319BWUI; N-Cyclohexy-4-(imidazol-4-yl)-1-piperidinecarbothioamide; CHEMBL260374; N-cyclohexyl-4-(1H-imidazol-5-yl)piperidine-1-carbothioamide; CHEBI:81391; N-Cyclohexyl-4-(1H-imidazol-5-yl)-1-piperidinecarbothioamide; Tocris-0644; Lopac-T-123; Lopac0_001214; SCHEMBL2235762; GTPL1267; AC1MI071; BDBM22914; DTXSID50147555; MolPort-023-275-907; MolPort-015-163-994
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| Drug Type |
Small molecular drug
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| Indication | Cognitive impairment [ICD-11: 6D71; ICD-10: F06.7] | Terminated | [1], [2] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C15H24N4S
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| Canonical SMILES |
C1CCC(CC1)NC(=S)N2CCC(CC2)C3=CN=CN3
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| InChI |
1S/C15H24N4S/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-11-17-14/h10-13H,1-9H2,(H,16,17)(H,18,20)
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| InChIKey |
QKDDJDBFONZGBW-UHFFFAOYSA-N
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| CAS Number |
CAS 106243-16-7
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| PubChem Compound ID | ||||
| PubChem Substance ID |
5646740, 5849660, 11111845, 11113618, 14922585, 14922586, 24536774, 26751818, 36104185, 47721703, 49846728, 50015455, 50104511, 51054761, 57353295, 85083113, 85209332, 85788104, 90341317, 96024154, 99206112, 103566780, 103941424, 111640044, 124750325, 124881519, 124881520, 124881521, 126591031, 129034527, 134340541, 134340617, 135143800, 135651258, 135698493, 135756358, 137185856, 142231014, 142667105, 179149541, 179235817, 184581023, 198982124, 223446365, 228362787, 241181796, 241377426, 249617185, 250134232
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| ChEBI ID |
CHEBI:81391
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Histamine H3 receptor (H3R) | Target Info | Antagonist | [3], [4] |
| Histamine H4 receptor (H4R) | Target Info | Antagonist | [3], [5], [6] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Reactome | Histamine receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | Monoamine Transport | |||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1267). | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004362) | |||
| REF 3 | The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20. | |||
| REF 4 | Combined histamine H1 and H3 receptor blockade produces nasal decongestion in an experimental model of nasal congestion. Am J Rhinol. 1999 Sep-Oct;13(5):391-9. | |||
| REF 5 | Role of histamine in short- and long-term effects of methamphetamine on the developing mouse brain. J Neurochem. 2008 Nov;107(4):976-86. | |||
| REF 6 | Role of histamine H3 and H4 receptors in mechanical hyperalgesia following peripheral nerve injury. Neuroimmunomodulation. 2007;14(6):317-25. | |||
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