Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D05GDS
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| Drug Name |
N-(arylalkyl)-1H-indole-2-sulfonic acid amide derivative 2
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| Synonyms |
PMID26161824-Compound-187
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| Drug Type |
Small molecular drug
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| Indication | Obesity [ICD-11: 5B81; ICD-10: E66; ICD-9: 278] | Patented | [1] | |
| Company |
THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN GREIG, lain Robert ROSS, Ruth Alexandra PERTWEE, Roger Guy TREMBLEAU, Laurent Alain Claude ABDEL-RAHMAN, Mostafa Hamed BAILLIE, Gemma Louise
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| Structure |
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Download2D MOL |
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| Formula |
C21H17FN2O2S
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| Canonical SMILES |
C1=CC=C2C(=C1)C=C(N2)S(=O)(=O)NCC3=CC=C(C=C3)C4=CC=C(C=C4)F
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| InChI |
1S/C21H17FN2O2S/c22-19-11-9-17(10-12-19)16-7-5-15(6-8-16)14-23-27(25,26)21-13-18-3-1-2-4-20(18)24-21/h1-13,23-24H,14H2
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| InChIKey |
ZYXQIXCJTWOQOB-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Cannabinoid receptor 1 (CB1) | Target Info | Antagonist | [1] |
| Target's Patent Info | Cannabinoid receptor 1 (CB1) | Target's Patent Info | [1] | |
| KEGG Pathway | Rap1 signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Retrograde endocannabinoid signaling | ||||
| Panther Pathway | Endogenous cannabinoid signaling | |||
| Pathway Interaction Database | N-cadherin signaling events | |||
| Reactome | Class A/1 (Rhodopsin-like receptors) | |||
| G alpha (i) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Small Ligand GPCRs | ||||
| BDNF signaling pathway | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. | |||
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