Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D05GOM
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| Former ID |
DIB000570
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| Drug Name |
S-20928
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| Synonyms |
152302-33-5; S-20928; N-(2-naphthalen-1-ylethyl)cyclobutanecarboxamide; N-(2-(1-Naphthalenyl)ethyl)cyclobutanecarboxamide; Cyclobutanecarboxamide,N-[2-(1-naphthalenyl)ethyl]-; ACMC-20n6et; AC1L2SR8; S 20928; CHEMBL12296; ZINC5833; GTPL1360; SCHEMBL6254856; CTK4C7390; DTXSID00164994; MolPort-009-303-106; GLXSBZGTGMPDKH-UHFFFAOYSA-N; AKOS030612657; MCULE-2771118083; N-[2-(1-naphthyl)ethyl]cyclobutanecarboxamide; S20928; n-[2-naphth-1-yl-ethyl]-cyclobutyl carboxamide; L000529; N-[2-(naphthalen-1-yl)ethyl]cyclobutanecarboxamide
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| Drug Type |
Small molecular drug
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| Indication | Sleep-wake disorder [ICD-11: 7A00-7B2Z; ICD-10: G47] | Terminated | [1], [2] | |
| Company |
Servier
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| Structure |
 |
Download2D MOL |
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| Formula |
C17H19NO
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| Canonical SMILES |
C1CC(C1)C(=O)NCCC2=CC=CC3=CC=CC=C32
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| InChI |
1S/C17H19NO/c19-17(15-8-4-9-15)18-12-11-14-7-3-6-13-5-1-2-10-16(13)14/h1-3,5-7,10,15H,4,8-9,11-12H2,(H,18,19)
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| InChIKey |
GLXSBZGTGMPDKH-UHFFFAOYSA-N
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| CAS Number |
CAS 152302-33-5
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Melatonin receptor type 1A (MTNR1A) | Target Info | Modulator | [3] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Circadian entrainment | ||||
| Reactome | Class A/1 (Rhodopsin-like receptors) | |||
| G alpha (i) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Small Ligand GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1360). | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006913) | |||
| REF 3 | Effects of two melatonin analogues, S-20098 and S-20928, on melatonin receptors in the pars tuberalis of the rat. J Pineal Res. 1998 Oct;25(3):172-6. | |||
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