Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D05GPO
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| Former ID |
DAP001062
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| Drug Name |
Olopatadine
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| Synonyms |
Allelock; Opatanol; Pataday; Patanase; Patanol; OLOPATADINE HCl; OLOPATADINE HYDROCHLORIDE; ALO4943A; HCl of KW 4679; KW 4679; O0361; AL-4943A; ALO-4943A; Allelock (TN); KW-4679; KW-4943A; Olopatadine [INN:BAN]; Pataday (TN); Patanase (TN); Patanol S (TN); {(11Z)-11-[3-(dimethylamino)propylidene]-6,11-dihydrodibenzo[b,e]oxepin-2-yl}acetic acid; 11-((Z)-3-(Dimethylamino)propylidene)-6,11-dihydrodibenz(b,e)oxepin-2-acetic acid; 11-((Z)-3-(Dimethylamino)propylidene)-6,11-dihydrodibenz(b,e)oxepin-2-acetic acid hydrochloride; 11-((Z)-3-(Dimethylamino)propylidene)-6,11-dihydrodibenz(b,e)oxepin-2-acetic acid, hydrochloride; 11-(3-(dimethylamino)propylidene)-6,11-dihydrodibenz(b,e)oxepin-2-acetic acid; 2-[(11Z)-11-[3-(dimethylamino)propylidene]-6H-benzo[c][1]benzoxepin-2-yl]acetic acid; 2-[(11Z)-11-[3-(dimethylamino)propylidene]-6H-benzo[c][1]benzoxepin-2-yl]acetic acid hydrochloride
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| Drug Type |
Small molecular drug
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| Indication | Allergic conjunctivitis [ICD-11: 9A60.02; ICD-10: H10.1] | Approved | [1], [2] | |
| Ocular allergy [ICD-11: 4A81] | Phase 3 | [1], [2] | ||
| Therapeutic Class |
Antiallergic Agents
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| Company |
Alcon
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| Structure |
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Download2D MOL |
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| Formula |
C21H23NO3
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| Canonical SMILES |
CN(C)CCC=C1C2=CC=CC=C2COC3=C1C=C(C=C3)CC(=O)O
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| InChI |
1S/C21H23NO3/c1-22(2)11-5-8-18-17-7-4-3-6-16(17)14-25-20-10-9-15(12-19(18)20)13-21(23)24/h3-4,6-10,12H,5,11,13-14H2,1-2H3,(H,23,24)/b18-8-
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| InChIKey |
JBIMVDZLSHOPLA-LSCVHKIXSA-N
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| CAS Number |
CAS 113806-05-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9991, 8616501, 14851325, 39289993, 46506025, 49830421, 50064183, 50339892, 53788070, 57357997, 85209467, 92308886, 93166443, 96024980, 103916408, 113854504, 117867960, 118048374, 118313762, 124974068, 126682737, 131839756, 134338320, 135076611, 137005453, 137233305, 142121621, 160964111, 163669016, 170499432, 175266654, 175435402, 176484058, 176484854, 177749229, 178103823, 179149624, 179225235, 184623003, 223655359, 224131802, 226396615, 251916843, 251918082, 251960673, 252391226, 252429690, 252671957
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| ChEBI ID |
CHEBI:94593
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| ADReCS Drug ID | BADD_D01605 ; BADD_D01606 | |||
| SuperDrug ATC ID |
R01AC08; S01GX09
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| SuperDrug CAS ID |
cas=113806056
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Histamine H1 receptor (H1R) | Target Info | Antagonist | [2] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| Panther Pathway | Histamine H1 receptor mediated signaling pathway | |||
| Reactome | Histamine receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | Monoamine GPCRs | |||
| GPCRs, Class A Rhodopsin-like | ||||
| IL-4 Signaling Pathway | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7249). | |||
| REF 2 | Emerging drugs for ocular allergy. Expert Opin Emerg Drugs. 2005 Aug;10(3):505-20. | |||
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