Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D05IPF
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| Former ID |
DNCL003355
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| Drug Name |
Kombiglyze XR/Komboglyze FDC
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| Synonyms |
Metformin mixture with saxagliptin; 1198772-17-6; Kombiglyze; Komboglyze; Kombiglyze XR; Saxagliptin / metformin; Metformin / saxagliptin
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| Drug Type |
Small molecular drug
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| Indication | Diabetic complication [ICD-11: 5A2Y; ICD-9: 253.5, 588.1] | Approved | [1] | |
| Company |
AstraZeneca
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| Structure |
 |
Download2D MOL |
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| Formula |
C22H36N8O2
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| Canonical SMILES |
CN(C)C(=N)N=C(N)N.C1C2CC2N(C1C#N)C(=O)C(C34CC5CC(C3)CC(C5)(C4)O)N
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| InChI |
1S/C18H25N3O2.C4H11N5/c19-8-13-2-12-3-14(12)21(13)16(22)15(20)17-4-10-1-11(5-17)7-18(23,6-10)9-17;1-9(2)4(7)8-3(5)6/h10-15,23H,1-7,9,20H2;1-2H3,(H5,5,6,7,8)/t10?,11?,12?,13-,14-,15+,17?,18?;/m1./s1
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| InChIKey |
QUKZWYNGKYRRKE-RIKNOMPASA-N
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| CAS Number |
CAS 1198772-17-6
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Dipeptidyl peptidase 4 (DPP-4) | Target Info | Modulator | [2] |
| KEGG Pathway | Protein digestion and absorption | |||
| NetPath Pathway | IL2 Signaling Pathway | |||
| TGF_beta_Receptor Signaling Pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | KOMBIGLYZE XR tablets approved in the US for the treatment of type 2 diabetes mellitus in adults | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1612). | |||
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