Drug Information
Drug General Information | Top | |||
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Drug ID |
D05NBD
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Former ID |
DIB011000
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Drug Name |
MONTIRELIN TETRAHYDRATE
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Synonyms |
NS-3; Montirelin tetrahydrate; Remnos (Nippon Shinyaku, JP); (2R,5R)-N-(2-Methyl-3-oxothiomorpholin-5-ylcarbonyl)-L-histidyl-L-prolinamide tetrahydrate
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Drug Type |
Small molecular drug
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Indication | Pain [ICD-11: MG30-MG3Z] | Discontinued in Preregistration | [1] | |
Structure |
Download2D MOL
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Formula |
C17H32N6O8S
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Canonical SMILES |
CC1C(=O)NC(CS1)C(=O)NC(CC2=CN=CN2)C(=O)N3CCCC3C(=O)N.O.O.O.O
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InChI |
1S/C17H24N6O4S.4H2O/c1-9-15(25)22-12(7-28-9)16(26)21-11(5-10-6-19-8-20-10)17(27)23-4-2-3-13(23)14(18)24;;;;/h6,8-9,11-13H,2-5,7H2,1H3,(H2,18,24)(H,19,20)(H,21,26)(H,22,25);4*1H2/t9-,11+,12+,13+;;;;/m1..../s1
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InChIKey |
LYTHVCBIYIODIA-UVZXXTSMSA-N
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Thyrotropin-releasing hormone receptor (TRHR) | Target Info | Modulator | [2], [3] |
KEGG Pathway | Calcium signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
Panther Pathway | Thyrotropin-releasing hormone receptor signaling pathway | |||
Reactome | Peptide ligand-binding receptors | |||
G alpha (q) signalling events | ||||
WikiPathways | GPCRs, Class A Rhodopsin-like | |||
Gastrin-CREB signalling pathway via PKC and MAPK | ||||
Peptide GPCRs | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001824) | |||
REF 2 | Montirelin hydrate (NS-3), a TRH analog, improved the disturbance of consciousness caused by head concussion and pentobarbital in mice. Nihon Yakurigaku Zasshi. 1996 May;107(5):237-45. | |||
REF 3 | Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36. |
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