Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D05OAE
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| Former ID |
DNC014881
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| Drug Name |
(12E,20Z,18S)-8-hydroxyvariabilin
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| Synonyms |
(12E,20Z,18S)-8-hydroxyvariabilin; GTPL4072
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C25H36O5
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| Canonical SMILES |
CC1=C(C(=CC(C)CCCC(=CCCC(C)(CCCC2=COC=C2)O)C)OC1=O)O
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| InChI |
1S/C25H36O5/c1-18(8-5-9-19(2)16-22-23(26)20(3)24(27)30-22)10-6-13-25(4,28)14-7-11-21-12-15-29-17-21/h10,12,15-17,19,26,28H,5-9,11,13-14H2,1-4H3/b18-10+,22-16-/t19-,25?/m0/s1
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| InChIKey |
QFBUNOKEKXMSCV-UYYPKTQPSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glycine receptor (GlyR) | Target Info | Inhibitor | [2] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Reactome | Ligand-gated ion channel transport | |||
| WikiPathways | Iron uptake and transport | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4072). | |||
| REF 2 | Ircinialactams: subunit-selective glycine receptor modulators from Australian sponges of the family Irciniidae. Bioorg Med Chem. 2010 Apr 15;18(8):2912-9. | |||
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