Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D05OBK
|
|||
| Former ID |
DCL000520
|
|||
| Drug Name |
DwLIP-GCGRrx
|
|||
| Synonyms |
UNII-T450D0Q71D; 1-Nitro-9-(3-dimethylaminopropylamino)-acridine dihydrochloride; 6514-85-8; Nitracrine HCl; ACRIDINE, 9-((3-(DIMETHYLAMINO)PROPYL)AMINO)-1-NITRO-, DIHYDROCHLORIDE; T450D0Q71D; 1,3-Propanediamine, N,N-dimethyl-N'-(1-nitro-9-acridinyl)-, dihydrochloride; CCRIS 9297; AC1L2LHF; SCHEMBL1652148; LS-14357; 1-NITRO-9-(DIMETHYLAMINOPROPYLAMINO)ACRIDINE DIHYDROCHLORIDE; dimethyl-[3-[(1-nitroacridin-9-yl)azaniumyl]propyl]azanium dichloride
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Diabetic complication [ICD-11: 5A2Y; ICD-9: 253.5, 588.1] | Investigative | [1] | |
| Company |
ISIS
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C18H22Cl2N4O2
|
|||
| Canonical SMILES |
C[NH+](C)CCC[NH2+]C1=C2C(=NC3=CC=CC=C31)C=CC=C2[N+](=O)[O-].[Cl-].[Cl-]
|
|||
| InChI |
1S/C18H20N4O2.2ClH/c1-21(2)12-6-11-19-18-13-7-3-4-8-14(13)20-15-9-5-10-16(17(15)18)22(23)24;;/h3-5,7-10H,6,11-12H2,1-2H3,(H,19,20);2*1H
|
|||
| InChIKey |
XBHIADYHFGJGSK-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 6514-85-8
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glucagon receptor (GCGR) | Target Info | Binder | [1] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Glucagon signaling pathway | ||||
| Reactome | Glucagon signaling in metabolic regulation | |||
| G alpha (q) signalling events | ||||
| G alpha (s) signalling events | ||||
| Glucagon-type ligand receptors | ||||
| WikiPathways | GPCRs, Class B Secretin-like | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Integration of energy metabolism | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2009). | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.