Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D05OVC
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| Former ID |
DNC000261
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| Drug Name |
Atipamezole
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| Synonyms |
Atipamezole; 104054-27-5; Antisedan; MPV-1248; MPV 1248; 4-(2-Ethyl-2-indanyl)imidazole; 4-(2-ethyl-2,3-dihydro-1h-inden-2-yl)-1h-imidazole; Atipamezolum [Latin]; Atipamezol [Spanish]; UNII-03N9U5JAF6; 1H-Imidazole, 4-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-; 03N9U5JAF6; 5-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole; NCGC00182707-01; Zeolite, type: ZSM-5; DSSTox_CID_29061; DSSTox_RID_83274; DSSTox_GSID_49135; 5-(2-ethyl-1,3-dihydroinden-2-yl)-1H-imidazole; antipamezole; Atipamezolum; Atipamezol; C14H16N2
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| Drug Type |
Small molecular drug
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| Indication | Male sexual disorder [ICD-11: HA02.0] | Discontinued in Phase 2 | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C14H16N2
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| Canonical SMILES |
CCC1(CC2=CC=CC=C2C1)C3=CN=CN3
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| InChI |
1S/C14H16N2/c1-2-14(13-9-15-10-16-13)7-11-5-3-4-6-12(11)8-14/h3-6,9-10H,2,7-8H2,1H3,(H,15,16)
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| InChIKey |
HSWPZIDYAHLZDD-UHFFFAOYSA-N
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| CAS Number |
CAS 104054-27-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
8194562, 12013913, 14773354, 14797752, 17397158, 43127666, 47657152, 47805604, 50064094, 57318128, 78674358, 85175697, 85209534, 92098499, 92718886, 103132746, 103422418, 104350171, 117521456, 118842421, 124894115, 124894116, 125336964, 126621250, 126651461, 126669987, 126731968, 128108424, 131342381, 134339731, 135028047, 137097620, 137239415, 140410512, 143493261, 144206556, 152039665, 152235379, 162249025, 162308961, 162770978, 164830387, 170466187, 172912863, 174525938, 175266036, 179149509, 179293702, 184526053, 196106036
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adrenergic receptor Alpha-2 (ADRA2) | Target Info | Antagonist | [2] |
| References | Top | |||
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| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000275) | |||
| REF 2 | Low doses of alpha 2-adrenoceptor antagonists augment spinal morphine analgesia and inhibit development of acute and chronic tolerance. Br J Pharmacol. 2008 Dec;155(8):1264-78. | |||
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