Drug Information
Drug General Information | Top | |||
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Drug ID |
D05SLY
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Former ID |
DIB020950
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Drug Name |
SK1-I
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Synonyms |
BML-258
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL
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Formula |
C17H27NO2
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Canonical SMILES |
CCCCCC1=CC=C(C=C1)C=CC(C(CO)NC)O
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InChI |
1S/C17H27NO2/c1-3-4-5-6-14-7-9-15(10-8-14)11-12-17(20)16(13-19)18-2/h7-12,16-20H,3-6,13H2,1-2H3/b12-11+/t16-,17+/m1/s1
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InChIKey |
JYEXUQKROPHSEF-SFDDJJRUSA-N
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Sphingosine kinase 1 (SPHK1) | Target Info | Inhibitor | [2] |
BioCyc | Sphingosine and sphingosine-1-phosphate metabolism | |||
KEGG Pathway | Sphingolipid metabolism | |||
Metabolic pathways | ||||
Calcium signaling pathway | ||||
Sphingolipid signaling pathway | ||||
VEGF signaling pathway | ||||
Fc gamma R-mediated phagocytosis | ||||
Tuberculosis | ||||
NetPath Pathway | TCR Signaling Pathway | |||
TNFalpha Signaling Pathway | ||||
Panther Pathway | Angiogenesis | |||
VEGF signaling pathway | ||||
Pathway Interaction Database | Fc-epsilon receptor I signaling in mast cells | |||
Beta3 integrin cell surface interactions | ||||
S1P1 pathway | ||||
Sphingosine 1-phosphate (S1P) pathway | ||||
PDGFR-beta signaling pathway | ||||
Reactome | Sphingolipid de novo biosynthesis | |||
VEGFR2 mediated cell proliferation | ||||
WikiPathways | Signal Transduction of S1P Receptor | |||
Protein folding | ||||
Sphingolipid Metabolism |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6622). | |||
REF 2 | A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia. Blood. 2008 Aug 15;112(4):1382-91. |
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