Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D06BFP
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| Former ID |
DNC003896
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| Drug Name |
CGS-17867A
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| Synonyms |
Cgs-17867A; CHEMBL116842; 2-(4-Chloro-phenyl)-2,5,6,7,8,9-hexahydro-pyrazolo[4,3-c]quinolin-3-one; AC1L2T4E; SCHEMBL2287621; OJVURBSORBSWLX-UHFFFAOYSA-N; CGS-17867; BDBM50148320; 2-p-Tolyl-2,5,6,7,8,9-hexahydro-pyrazolo[4,3-c]quinolin-3-one; 2-(4-chlorophenyl)-6,7,8,9-tetrahydro-1H-pyrazolo[4,3-c]quinolin-3-one
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| Drug Type |
Small molecular drug
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| Indication | Alcohol dependence [ICD-11: 6C40.2; ICD-10: F10.2; ICD-9: 303] | Terminated | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C16H14ClN3O
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| Canonical SMILES |
C1CCC2=NC=C3C(=C2C1)NN(C3=O)C4=CC=C(C=C4)Cl
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| InChI |
1S/C16H14ClN3O/c17-10-5-7-11(8-6-10)20-16(21)13-9-18-14-4-2-1-3-12(14)15(13)19-20/h5-9,19H,1-4H2
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| InChIKey |
NZEIZTTWQRQFFV-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | GABA(A) receptor alpha-2 (GABRA2) | Target Info | Inhibitor | [2] |
| GABA(A) receptor gamma-2 (GABRG2) | Target Info | Inhibitor | [2] | |
| Gamma-aminobutyric acid receptor (GAR) | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Retrograde endocannabinoid signaling | ||||
| GABAergic synapse | ||||
| Morphine addiction | ||||
| Nicotine addiction | ||||
| Reactome | Ligand-gated ion channel transport | |||
| GABA A receptor activation | ||||
| WikiPathways | Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||
| Iron uptake and transport | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000696) | |||
| REF 2 | 2,5-Dihydropyrazolo[4,3-c]pyridin-3-ones: functionally selective benzodiazepine binding site ligands on the GABAA receptor. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3441-4. | |||
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