Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06CGB
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| Former ID |
DAP001209
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| Drug Name |
Desogestrel
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| Synonyms |
Cerazette; Desogen; Desogestrelum; Organon Brand of Desogestrel; ORG 2969; Desogestrelum [INN-Latin]; Desogestrel (USAN/INN); Desogestrel [USAN:BAN:INN]; Alpha-pregn-4-en-20-yn-17-ol, 13-Ethyl-11-methylene-18,19-dinor-17; (17alpha)-13-Ethyl-11-methylene-18,19-dinorpregn-4-en-20-yn-17-ol; (8S,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-11-methylidene-1,2,3,6,7,8,9,10,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-ol; 13 Ethyl 11 methylene 18,19 dinor 17 alpha pregn 4 en 20 yn 17 ol; 13-Ethyl-11-methylene-18,19-dinor-17 alpha-pregn-4-en-20-yn-17-ol; 13-Ethyl-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-17-ol; 17alpha-ethynyl-11-methylidene-18a-homo-estr-4-en-17beta-ol
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| Drug Type |
Small molecular drug
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| Indication | Contraception [ICD-11: QA21] | Approved | [1], [2] | |
| Therapeutic Class |
Contraceptive Agents
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| Structure |
 |
Download2D MOL |
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| Formula |
C22H30O
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| Canonical SMILES |
CCC12CC(=C)C3C(C1CCC2(C#C)O)CCC4=CCCCC34
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| InChI |
1S/C22H30O/c1-4-21-14-15(3)20-17-9-7-6-8-16(17)10-11-18(20)19(21)12-13-22(21,23)5-2/h2,8,17-20,23H,3-4,6-7,9-14H2,1H3/t17-,18-,19-,20+,21-,22-/m0/s1
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| InChIKey |
RPLCPCMSCLEKRS-BPIQYHPVSA-N
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| CAS Number |
CAS 54024-22-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9831, 7849426, 7979047, 8176865, 12015338, 14923366, 14923367, 24702329, 34706666, 46505739, 48415858, 49963130, 50112703, 53787301, 56352943, 57312489, 71831485, 78875517, 92717926, 103566300, 104335749, 117391777, 126621867, 126653606, 126671043, 134338449, 135003936, 135727366, 136197332, 137002814, 140504081, 144206006, 152102617, 160963652, 162176918, 163133991, 164152385, 164756093, 175267238, 178103644, 179150590, 184552366, 196105624, 206246236, 223673205, 223974105, 226426388, 241094430
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| ChEBI ID |
CHEBI:4453
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| ADReCS Drug ID | BADD_D00618 | |||
| SuperDrug ATC ID |
G03AC09
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| SuperDrug CAS ID |
cas=054024225
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Progesterone receptor (PGR) | Target Info | Modulator | [3] |
| KEGG Pathway | Oocyte meiosis | |||
| Progesterone-mediated oocyte maturation | ||||
| Pathway Interaction Database | Cellular roles of Anthrax toxin | |||
| Reactome | Nuclear signaling by ERBB4 | |||
| Nuclear Receptor transcription pathway | ||||
| WikiPathways | Ovarian Infertility Genes | |||
| Signaling by ERBB4 | ||||
| Nuclear Receptors | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7065). | |||
| REF 2 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
| REF 3 | Preclinical experience with two selective progesterone receptor modulators on breast and endometrium. Steroids. 2000 Oct-Nov;65(10-11):733-40. | |||
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