Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06DIH
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| Former ID |
DNC003110
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| Drug Name |
Furo[2,3d]Pyrimidine Antifolate
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| Synonyms |
Dpmmabg; furo[2,3d]pyrimidine antifolate; CHEMBL104829; 156595-85-6; N-[4-[(2,4-DIAMINOFURO[2,3D]PYRIMIDIN-5-YL)METHYL]METHYLAMINO]-BENZOYL]-L-GLUTAMATE; MOT; MTXO; AC1L4JTH; CTK4C9124; DTXSID50166105; 2-{4-[(2,4-Diamino-furo[2,3-d]pyrimidin-5-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid; BDBM50091145; AKOS030607152; DB02026; N-(4-(((2,4-Diaminofuro(2,3-d)pyrimidin-5-yl)methyl)methylamino)benzoyl)-L-glutamic acid; N-(4-(N-((2,4-Diamino-furo(2,3-d)pyrimidin-5-yl)methyl)methylamino)benzoyl)glutamic acid
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C20H22N6O6
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| Canonical SMILES |
CN(CC1=COC2=NC(=NC(=C12)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
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| InChI |
1S/C20H22N6O6/c1-26(8-11-9-32-18-15(11)16(21)24-20(22)25-18)12-4-2-10(3-5-12)17(29)23-13(19(30)31)6-7-14(27)28/h2-5,9,13H,6-8H2,1H3,(H,23,29)(H,27,28)(H,30,31)(H4,21,22,24,25)/t13-/m0/s1
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| InChIKey |
WXINNGCGSCFUCR-ZDUSSCGKSA-N
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| CAS Number |
CAS 156595-85-6
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Polypeptide deformylase (PDF) | Target Info | Inhibitor | [1] |
| Pathwhiz Pathway | Folate Metabolism | |||
| Pterine Biosynthesis | ||||
| Reactome | E2F mediated regulation of DNA replication | |||
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | ||||
| Metabolism of folate and pterines | ||||
| G1/S-Specific Transcription | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | |||
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