Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06DKU
|
|||
| Drug Name |
Amiodarone
|
|||
| Synonyms |
amiodarone; 1951-25-3; Cordarone; Amiodarona; Amiodaronum; Amjodaronum; Amiodaronum [INN-Latin]; Amiodarona [INN-Spanish]; Pacerone; L 3428; L-3428; UNII-N3RQ532IUT; C25H29I2NO3; SKF 33134-A; EINECS 217-772-1; CHEMBL633; BRN 1271711; N3RQ532; Amiodarone
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Ventricular tachycardia [ICD-11: BC71; ICD-10: I47] | Approved | [1] | |
| Coronavirus Disease 2019 (COVID-19) [ICD-11: 1D6Y] | Phase 2/3 | [2] | ||
| Therapeutic Class |
Antiviral Agents
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C25H29I2NO3
|
|||
| Canonical SMILES |
CCCCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC(=C(C(=C3)I)OCCN(CC)CC)I
|
|||
| InChI |
1S/C25H29I2NO3/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3
|
|||
| InChIKey |
IYIKLHRQXLHMJQ-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 1951-25-3
|
|||
| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:2663
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | HUMAN two pore channel subtype 2 (TPC2) | Target Info | Blocker | [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (ANDA) 204742. | |||
| REF 2 | ClinicalTrials.gov (NCT04351763) Amiodarone or Verapamil in COVID-19 Hospitalized Patients With Symptoms. U.S. National Institutes of Health. | |||
| REF 3 | Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV. Nat Commun. 2020 Mar 27;11(1):1620. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.