Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D06DLQ
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| Former ID |
DIB005941
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| Drug Name |
CGP-37849
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| Synonyms |
CGP-39551; CGP-40116; CGP-43487; Ethyl ester of CGP-37849; 4-methyl-APPA
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| Drug Type |
Small molecular drug
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| Indication | Neurological disorder [ICD-11: 6B60] | Discontinued in Phase 1 | [1], [2] | |
| Company |
Novartis AG
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| Structure |
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Download2D MOL |
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| Formula |
C6H12NO5P
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| Canonical SMILES |
CC(=CC(C(=O)O)N)CP(=O)(O)O
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| InChI |
1S/C6H12NO5P/c1-4(3-13(10,11)12)2-5(7)6(8)9/h2,5H,3,7H2,1H3,(H,8,9)(H2,10,11,12)/b4-2+
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| InChIKey |
BDYHNCZIGYIOGJ-DUXPYHPUSA-N
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| CAS Number |
CAS 127910-31-0
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | N-methyl-D-aspartate receptor (NMDAR) | Target Info | Modulator | [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4154). | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007917) | |||
| REF 3 | The competitive NMDA receptor antagonists CGP 37849 and CGP 39551 are potent, orally-active anticonvulsants in rodents. Naunyn Schmiedebergs Arch Pharmacol. 1990 Jul;342(1):61-6. | |||
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