Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D06ECJ
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| Drug Name |
Verapamil
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| Synonyms |
VERAPAMIL; Iproveratril; 52-53-9; Vasolan; Dilacoran; Isoptin; Falicard; Isoptine; Isoptimo; Finoptin; Calan; Verapamilo; Verapamilum; Verapamilum [INN-Latin]; Lekoptin; Verapamilo [INN-Spanish]; Isotopin; Calcan; Tarka; D-365; Securon; Verelan; Izoptin; Verapamil [USAN:INN:BAN]; CP-16533-1; Covera-HS; Verpamil; CCRIS 6749; Verelan PM; Isoptin SR; C; Verapamil
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| Drug Type |
Small molecular drug
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| Indication | Hypertension [ICD-11: BA00-BA04; ICD-9: 401] | Approved | [1] | |
| Coronavirus Disease 2019 (COVID-19) [ICD-11: 1D6Y] | Phase 2/3 | [2] | ||
| Therapeutic Class |
Antiviral Agents
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| Structure |
 |
Download2D MOL |
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| Formula |
C27H38N2O4
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| Canonical SMILES |
CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC
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| InChI |
1S/C27H38N2O4/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6/h9-12,17-18,20H,8,13-16H2,1-7H3
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| InChIKey |
SGTNSNPWRIOYBX-UHFFFAOYSA-N
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| CAS Number |
CAS 52-53-9
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:77733
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | HUMAN two pore channel subtype 2 (TPC2) | Target Info | Blocker | [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (ANDA) 071881. | |||
| REF 2 | ClinicalTrials.gov (NCT04351763) Amiodarone or Verapamil in COVID-19 Hospitalized Patients With Symptoms. U.S. National Institutes of Health. | |||
| REF 3 | Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV. Nat Commun. 2020 Mar 27;11(1):1620. | |||
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