Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06ESU
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| Former ID |
DIB007168
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| Drug Name |
AM-461
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| Indication | Respiratory disease [ICD-11: CB40] | Phase 1 | [1] | |
| Company |
Amira Pharmaceuticals Inc
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| Structure |
 |
Download2D MOL |
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| Formula |
C25H33NO5S
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| Canonical SMILES |
CC(C)(C)C(=O)NC1=CC(=C(C=C1)OC2=C(C=CC(=C2)CC(=O)O)OC)CSC(C)(C)C
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| InChI |
1S/C25H33NO5S/c1-24(2,3)23(29)26-18-9-11-19(17(14-18)15-32-25(4,5)6)31-21-12-16(13-22(27)28)8-10-20(21)30-7/h8-12,14H,13,15H2,1-7H3,(H,26,29)(H,27,28)
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| InChIKey |
SDHFXINHZHARIB-UHFFFAOYSA-N
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| CAS Number |
CAS 1203503-64-3
|
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Prostaglandin D2 receptor 2 (PTGDR2) | Target Info | Antagonist | [2] |
| Reactome | Prostanoid ligand receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031337) | |||
| REF 2 | A novel DP2 receptor antagonist (AM-461): a patent evaluation of WO2011085033. Expert Opin Ther Pat. 2011 Dec;21(12):1931-6. | |||
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