Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D06FIF
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| Former ID |
DNC013525
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| Drug Name |
CP-376395
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| Synonyms |
CP-376395; CP 376395; 175140-00-8; UNII-5113G7FP34; 3,6-Dimethyl-N-(Pentan-3-Yl)-2-(2,4,6-Trimethylphenoxy)pyridin-4-Amine; 5113G7FP34; VIZBSVDBNLAVAW-UHFFFAOYSA-N; 1Q5; CP376395; 4k5y; SCHEMBL123421; GTPL3496; CHEMBL270948; DTXSID0047298; BDBM20966; MolPort-009-194-134; KS-00002WT7; 2-Aryloxy-4-alkylaminopyridine, 3a; ZINC14975027; AKOS015994585; 4-Pyridinamine, N-(1-ethylpropyl)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-; GD-0065; CS-7833; API0007847; compound 3a [PMID: 18288792]; HY-14130; KB-76174; CP-376,395; CP 376,395
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C21H30N2O
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| Canonical SMILES |
CCC(CC)NC1=C(C(=NC(=C1)C)OC2=C(C=C(C=C2C)C)C)C
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| InChI |
1S/C21H30N2O/c1-8-18(9-2)23-19-12-16(6)22-21(17(19)7)24-20-14(4)10-13(3)11-15(20)5/h10-12,18H,8-9H2,1-7H3,(H,22,23)
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| InChIKey |
VIZBSVDBNLAVAW-UHFFFAOYSA-N
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| CAS Number |
CAS 175140-00-8
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Corticotropin-releasing factor receptor 1 (CRHR1) | Target Info | Inhibitor | [2] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Long-term depression | ||||
| NetPath Pathway | TNFalpha Signaling Pathway | |||
| Panther Pathway | Cortocotropin releasing factor receptor signaling pathway | |||
| Reactome | Class B/2 (Secretin family receptors) | |||
| G alpha (s) signalling events | ||||
| WikiPathways | GPCRs, Class B Secretin-like | |||
| Myometrial Relaxation and Contraction Pathways | ||||
| Corticotropin-releasing hormone | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3496). | |||
| REF 2 | 2-aryloxy-4-alkylaminopyridines: discovery of novel corticotropin-releasing factor 1 antagonists. J Med Chem. 2008 Mar 13;51(5):1385-92. | |||
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