Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D06HIO
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| Former ID |
DIB000628
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| Drug Name |
Istaroxime
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| Synonyms |
Debio-0614; PST-2107; PST-2744; PST-2915; ST-2744; Digitalis-like compounds, Sigma-Tau; Sodium/potassium-ATPase inhibitors (infusion, cardiac failure), Sigma-Tau/Debiopharm; Na(+)-/K(+)-ATPase inhibitors (cardiac failure), Sigma-Tau; Na(+)-/K(+)-ATPase inhibitors (infusion, cardiac failure), Sigma-Tau/ Debiopharm
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| Drug Type |
Small molecular drug
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| Indication | Cardiac disease [ICD-11: BA00-BE2Z; ICD-10: I50] | Discontinued in Phase 2 | [1] | |
| Company |
Sigma-Tau Pharmaceuticals
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| Structure |
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Download2D MOL |
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| Formula |
C21H32N2O3
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| Canonical SMILES |
CC12CCC(=NOCCN)CC1C(=O)CC3C2CCC4(C3CCC4=O)C
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| InChI |
1S/C21H32N2O3/c1-20-7-5-13(23-26-10-9-22)11-17(20)18(24)12-14-15-3-4-19(25)21(15,2)8-6-16(14)20/h14-17H,3-12,22H2,1-2H3/b23-13+/t14-,15-,16-,17+,20+,21-/m0/s1
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| InChIKey |
MPYLDWFDPHRTEG-PAAYLBSLSA-N
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| CAS Number |
CAS 203737-93-3
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Sodium/potassium-transporting ATPase (SPT ATPase) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010607) | |||
| REF 2 | Novel analogues of istaroxime, a potent inhibitor of Na+,K+-ATPase: synthesis and structure-activity relationship. J Med Chem. 2008 Aug 14;51(15):4601-8. | |||
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