Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06HXC
|
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| Former ID |
DNC001043
|
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| Drug Name |
NPY-1 antagonist
|
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| Drug Type |
Small molecular drug
|
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| Indication | Eating disorder [ICD-11: 6B82; ICD-9: 307.5] | Investigative | [1] | |
| Company |
Pfizer
|
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| Structure |
 |
Download2D MOL |
||
| Formula |
C30H35N5O3
|
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| Canonical SMILES |
C1CC(OC1)CNC(=O)NC(=NCC2=CC=CC(=C2)CNC(=O)C(CC3=CC=CC=C3)C4=CC=CC=C4)N
|
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| InChI |
1S/C30H35N5O3/c31-29(35-30(37)34-21-26-15-8-16-38-26)33-20-24-12-7-11-23(17-24)19-32-28(36)27(25-13-5-2-6-14-25)18-22-9-3-1-4-10-22/h1-7,9-14,17,26-27H,8,15-16,18-21H2,(H,32,36)(H4,31,33,34,35,37)
|
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| InChIKey |
BSGMHDGHMYUSDC-UHFFFAOYSA-N
|
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Neuropeptide Y receptor type 1 (NPY1R) | Target Info | Antagonist | [2] |
| KEGG Pathway | cAMP signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| NetPath Pathway | FSH Signaling Pathway | |||
| Reactome | Peptide ligand-binding receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Peptide GPCRs | ||||
| Endothelin Pathways | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Neuropeptide Y receptor antagonists. IDrugs. 2001 Aug;4(8):920-7. | |||
| REF 2 | Emerging drugs for eating disorder treatment. Expert Opin Emerg Drugs. 2006 May;11(2):315-36. | |||
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