Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D06JRD
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| Former ID |
DIB002354
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| Drug Name |
Metamizole
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| Synonyms |
Dipyrone; dipyrone; Analgin; Metamizole sodium; Methampyrone; Novalgin; sulpyrine; 68-89-3; Neomelurbrin; Methylmelubrin; Algocalmin; Optalgin; Novalgetol; Sulpyrin; Pyralgin; Narone; Novaminsulfone; Novamidazophen; Nevralgina; Pharmalgine; Algopyrine; Farmolisina; Pyretin; Keypyrone; Analgine; Noveltex; Fevonil; Diprofarn; Dimethone; Alginodia; Pyrojec; Paralgin; Metilon; Metapyrin; Gifaril; Bonpyrin; Sulpin; Conmel; Barone; Neo-melubrine; Di-podil; Aminopyrine sodium sulfonate; Novaminsulfonum; Novaminsulfon; Metamizolum natricum
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| Drug Type |
Small molecular drug
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| Indication | Fever [ICD-11: MG26] | Withdrawn from market | [1], [2] | |
| Pain [ICD-11: MG30-MG3Z] | Withdrawn from market | [1] | ||
| Company |
Aventis SA
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| Structure |
 |
Download2D MOL |
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| Formula |
C13H17N3O4S
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| Canonical SMILES |
CC1=C(C(=O)N(N1C)C2=CC=CC=C2)N(C)CS(=O)(=O)O
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| InChI |
1S/C13H17N3O4S/c1-10-12(14(2)9-21(18,19)20)13(17)16(15(10)3)11-7-5-4-6-8-11/h4-8H,9H2,1-3H3,(H,18,19,20)
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| InChIKey |
LVWZTYCIRDMTEY-UHFFFAOYSA-N
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| CAS Number |
CAS 50567-35-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
3141602, 7978471, 8149975, 8671880, 10321896, 11112965, 14924439, 25672721, 26612465, 26680273, 26748775, 26748776, 29225232, 46509035, 48413695, 49857349, 49991316, 53787029, 57288770, 57406347, 79371109, 79371110, 85091098, 88837636, 92124570, 92125891, 92307887, 92741959, 96024880, 99301722, 103588113, 103914375, 109768588, 118047367, 121363562, 124637172, 124882743, 124882744, 125311960, 125329714, 126408303, 126677934, 134339964, 134971374, 137002916, 141701141, 143432632, 143832172, 144204310, 144207695
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| ChEBI ID |
CHEBI:62088
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Prostaglandin G/H synthase 1 (COX-1) | Target Info | Inhibitor | [3] |
| BioCyc | C20 prostanoid biosynthesis | |||
| KEGG Pathway | Arachidonic acid metabolism | |||
| Metabolic pathways | ||||
| Platelet activation | ||||
| Serotonergic synapse | ||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| Panther Pathway | Inflammation mediated by chemokine and cytokine signaling pathway | |||
| Pathwhiz Pathway | Arachidonic Acid Metabolism | |||
| WikiPathways | Prostaglandin Synthesis and Regulation | |||
| Arachidonic acid metabolism | ||||
| Phase 1 - Functionalization of compounds | ||||
| Eicosanoid Synthesis | ||||
| Selenium Micronutrient Network | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | ClinicalTrials.gov (NCT02181920) Metamizol for the Treatment of Neoplastic Chronic Pain. U.S. National Institutes of Health. | |||
| REF 3 | Mechanisms of action of paracetamol and related analgesics. Inflammopharmacology. 2003;11(4):401-13. | |||
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