Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06MUZ
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| Former ID |
DIB000113
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| Drug Name |
SDZ-87-469
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| Synonyms |
SDZ-87-469; AC1OCEZP; CHEMBL328466; SCHEMBL10689408; SDZ-87469
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| Drug Type |
Small molecular drug
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| Indication | Coronary artery disease [ICD-11: BA80; ICD-10: I25.1, I25.4] | Terminated | [1] | |
| Company |
Novartis AG
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| Structure |
 |
Download2D MOL
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| Formula |
C19H23Cl2NS
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| Canonical SMILES |
CC(C)(C)C#CC=CCN(C)CC1=C2C(=CC=C1)C(=CS2)Cl.Cl
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| InChI |
1S/C19H22ClNS.ClH/c1-19(2,3)11-6-5-7-12-21(4)13-15-9-8-10-16-17(20)14-22-18(15)16;/h5,7-10,14H,12-13H2,1-4H3;1H/b7-5+;
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| InChIKey |
INNKFGGCJAUIMK-GZOLSCHFSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Squalene monooxygenase (SQLE) | Target Info | Modulator | [2] |
| KEGG Pathway | Steroid biosynthesis | |||
| Sesquiterpenoid and triterpenoid biosynthesis | ||||
| Metabolic pathways | ||||
| Biosynthesis of secondary metabolites | ||||
| Biosynthesis of antibiotics | ||||
| Pathwhiz Pathway | Steroid Biosynthesis | |||
| Reactome | Cholesterol biosynthesis | |||
| Activation of gene expression by SREBF (SREBP) | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Chemotherapy of fungal diseases. 1990. Page(525-550). | |||
| REF 2 | Effects of squalene epoxidase inhibitors on Candida albicans. Antimicrob Agents Chemother. 1992 Aug;36(8):1779-81. | |||
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