Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06NEB
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| Former ID |
DNC006565
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| Drug Name |
Ac-hPhe-Leu-Phe-LeuVSMe
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| Synonyms |
CHEMBL379669; Ac-hPhe-Leu-Phe-LeuVSMe; BDBM50186702
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C35H50N4O6S
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| Canonical SMILES |
CC(C)CC(C=CS(=O)(=O)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC(C)C)NC(=O)C(CCC2=CC=CC=C2)NC(=O)C
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| InChI |
1S/C35H50N4O6S/c1-24(2)21-29(19-20-46(6,44)45)37-34(42)32(23-28-15-11-8-12-16-28)39-35(43)31(22-25(3)4)38-33(41)30(36-26(5)40)18-17-27-13-9-7-10-14-27/h7-16,19-20,24-25,29-32H,17-18,21-23H2,1-6H3,(H,36,40)(H,37,42)(H,38,41)(H,39,43)/b20-19+/t29-,30+,31+,32+/m1/s1
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| InChIKey |
UIUWSHIRBDIYGM-QLEUBDALSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Cathepsin B (CTSB) | Target Info | Inhibitor | [1] |
| Cathepsin S (CTSS) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Lysosome | |||
| Antigen processing and presentation | ||||
| Phagosome | ||||
| Tuberculosis | ||||
| NetPath Pathway | TCR Signaling Pathway | |||
| IL2 Signaling Pathway | ||||
| Leptin Signaling Pathway | ||||
| Reactome | Collagen degradation | |||
| Trafficking and processing of endosomal TLR | ||||
| Assembly of collagen fibrils and other multimeric structures | ||||
| MHC class II antigen presentation | ||||
| Endosomal/Vacuolar pathway | ||||
| Degradation of the extracellular matrix | ||||
| WikiPathways | Class I MHC mediated antigen processing & presentation | |||
| Trafficking and processing of endosomal TLR | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Optimization of subsite binding to the beta5 subunit of the human 20S proteasome using vinyl sulfones and 2-keto-1,3,4-oxadiazoles: syntheses and c... J Med Chem. 2006 May 18;49(10):2953-68. | |||
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