Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06NRX
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| Former ID |
DIB019667
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| Drug Name |
CV-1808
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| Synonyms |
2-phenylaminoadenosine; CV1808; CV 1808
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C16H18N6O4
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| Canonical SMILES |
C1=CC=C(C=C1)NC2=NC(=C3C(=N2)N(C=N3)C4C(C(C(O4)CO)O)O)N
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| InChI |
1S/C16H18N6O4/c17-13-10-14(21-16(20-13)19-8-4-2-1-3-5-8)22(7-18-10)15-12(25)11(24)9(6-23)26-15/h1-5,7,9,11-12,15,23-25H,6H2,(H3,17,19,20,21)/t9-,11-,12-,15-/m1/s1
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| InChIKey |
SCNILGOVBBRMBK-SDBHATRESA-N
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| CAS Number |
CAS 53296-10-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
12013194, 15349646, 17194554, 24263022, 24277727, 43529224, 46500437, 47731262, 48105194, 48179725, 48329065, 50104942, 56463249, 76713791, 90340587, 114786986, 123098325, 124801161, 129216550, 131342596, 131342601, 134223060, 135077682, 135650141, 135697850, 160830089, 162091865, 163094396, 163394380, 163842985, 172855790, 179150568, 189614605, 198962798, 204433920, 223556773, 227014025, 241093366, 252156055, 252502658
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adenosine A2b receptor (ADORA2B) | Target Info | Agonist | [2] |
| KEGG Pathway | Rap1 signaling pathway | |||
| Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| Vascular smooth muscle contraction | ||||
| Alcoholism | ||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| TCR Signaling Pathway | ||||
| Pathwhiz Pathway | Intracellular Signalling Through Adenosine Receptor A2b and Adenosine | |||
| Pathway Interaction Database | C-MYB transcription factor network | |||
| Reactome | Adenosine P1 receptors | |||
| G alpha (s) signalling events | ||||
| Surfactant metabolism | ||||
| WikiPathways | Nucleotide GPCRs | |||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 420). | |||
| REF 2 | Characterization of human A2A adenosine receptors with the antagonist radioligand [3H]-SCH 58261. Br J Pharmacol. 1997 Jun;121(3):353-60. | |||
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