Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06PJW
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| Former ID |
DIB019946
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| Drug Name |
GSK-1838705A
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| Synonyms |
GSK 1838705A; GSK1838705A
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C27H29FN8O3
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| Canonical SMILES |
CNC(=O)C1=C(C=CC=C1F)NC2=NC(=NC3=C2C=CN3)NC4=C(C=C5CCN(C5=C4)C(=O)CN(C)C)OC
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| InChI |
1S/C27H29FN8O3/c1-29-26(38)23-17(28)6-5-7-18(23)31-25-16-8-10-30-24(16)33-27(34-25)32-19-13-20-15(12-21(19)39-4)9-11-36(20)22(37)14-35(2)3/h5-8,10,12-13H,9,11,14H2,1-4H3,(H,29,38)(H3,30,31,32,33,34)
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| InChIKey |
HZTYDQRUAWIZRE-UHFFFAOYSA-N
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| CAS Number |
CAS 1116235-97-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
57290284, 57560329, 85028021, 103629211, 136348846, 136349563, 136367694, 141017575, 144116027, 152258421, 160647257, 162011614, 162038108, 162202695, 174006568, 174526213, 178102310, 180408479, 185990476, 189622850, 223705044, 224416783, 228335086, 237498825, 241377333, 242059764, 245173602, 247813672, 251963084, 252158607, 252160876, 252215504, 252443407, 252451201, 252671615
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| ChEBI ID |
CHEBI:93768
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | GSK1838705A inhibits the insulin-like growth factor-1 receptor and anaplastic lymphoma kinase and shows antitumor activity in experimental models of human cancers. Mol Cancer Ther. 2009 Oct;8(10):2811-20. | |||
| REF 2 | Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol. 2011 Oct 30;29(11):1046-51. | |||
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